MetaSystems offers a complete package for precise and effortless, automated TMA analysis based on the slide scanning platform Metafer.

The analysis of FISH signals in cell nuclei which are part of a solid tissue section requires special tools and methods. Based on the requirements of users and researchers, MetaSystems has now launched a dedicated software module for automated analysis of signals in tissues. The module is based on the powerful analysis engine of Metafer...

The Tissue Matching tools, which are included in the latest Metafer versions, now allow for easy segmentation, alignment, and matching of serial sections from the same tissue block. The system automatically generates overview images of two subsequent sections, and a convenient tool offers functionality to check and, if required, interactively match the images to each other.

MetaSystems is pleased to introduce Rapid Scoring (RS), a new method of analyzing FISH signals which combines manual scoring
strategies with the advantages of automated scoring. RS uses MetaCyte to automatically score cell signal patterns. All analyzed
cells are displayed in a gallery. Signal patterns are summarized in a convenient graph and a table. Immediately
after the scan technicians can begin categorizing cells with doubtful results. Categories are assigned to each cell using an
external keypad, and new categories (groups of cells) can be added any time.

Details of the mammalian erythrocyte micronucleus assay are described by the OECD Guideline #474 from 1997. With Metafer evaluation of the assay can be fully automated. Automation requires cellulose column purified samples according to the method described first by Romagna and Staniforth (Mutation Res.213, 1989).