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Newsletter 03/2018

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XCyting Locus-Specific Probes...

...for Aneuploidy Detection

MetaSystems is launching the XA AneuScore III Probe Kit combining the advantages of the well-known products XA AneuScore I and XA AneuScore II. XA AneuScore III comprises XA 13/18/21 and XA X/Y/18. The locus specific probes of XA 13/18/21 ensure clear and condensed signals with low background in interphase FISH assays. XA X/Y/18 centromeric signals allow the detection of sex chromosome aneuploidies supported by additional signals in the centromere region of chromosome 18.

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The XA AneuScore III Probe Kit contains different probe mixes, provided in separate test vials, for assessing chromosomal aneuploidies for chromosomes 13, 18, 21, X, and Y. The XA 13/18/21 mix of specific probes allows detecting copy number variations of chromosomes 13, 18, and 21. The green labeled probe hybridizes to a region at 13q14 including the RB1 locus, the blue (aqua) labeled probe hybridizes to a locus at 18q21, and the orange labeled probe hybridizes to a region at 21q22 including the DSCR4 (Down syndrome critical region 4).

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The XA X/Y/18 mix of specific probes allows detecting copy number variations for chromosomes X, Y, and 18. The probe mix is composed of repetitive sequences which hybridize to the centromeric region of chromosomes X in green, Y in orange, and 18 in blue (aqua).

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Copyright © 2019 MetaSystems Probes GmbH. All rights reserved.

MetaSystems Probes GmbH
1. Industriestrasse 7 | 68804 Altlussheim | Germany
info@metasystems-probes.com | metasystems-probes.com

Managing Directors: Dr. Thomas Lörch, Dr. Andreas Plesch
Court of Registry: Amtsgericht Mannheim
Company Registration No.: HRB 72 02 25
VAT Reg. No.: DE 296766271

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