24 painting probes specific for the 24 different human chromosomes, labeled with different fluorochromes. The excitation/emission spectra are comparable to the common aqua, green, orange, red and near infrared fluorochromes.

Also available as 120µl (2x60µl) D-0125-120-DI and as 600µl (10x60µl) D-0125-600-DI.

The principle of mFISH is based on combinatorial labeling of whole chromosome paints. For each chromosome, the different fluorochromes are mixed resulting in a unique color combination (see labeling scheme). The analysis is carried out after capturing grey scale images of each fluorochrome. For best separation of the different colors the filter sets used need to be highly selective assuring that crosstalk is reduced to a minimum. Multicolor FISH Analysis with MetaSystems‘ Isis supports the analysis by applying appropriate algorithms which leads to pseudo coloring of the different chromosome classes (color combinations). Each chromosome class will be displayed in a unique color. Translocations show up as color changes on individual chromosomes.

Please note that this product is not classified as an IVD product in the EU according to the REGULATION (EU) 2017/746 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 5 April 2017 on in vitro diagnostic medical devices and repealing Directive 98/79/EC and Commission Decision 2010/227/EU. It is marked as for ´Research Use Only´ (RUO).

Probe maps for selected products have been updated. These updates ensure a consistent presentation of all gaps larger than 10 kb including adjustments to markers, genes, and related elements. This update does not affect the device characteristics or product composition. Please refer to the list to find out which products now include updated probe maps.

Probe map details are based on UCSC Genome Browser GRCh37/hg19, with map components not to scale.

24XCyte hybridized to lymphocytes. Multiple translocations can be identified by conjunction of differently labeled chromosomal fragments.

• Speicher MR et al (1996) Nat Genet 12:368-375
• Fauth C and Speicher MR (2001) Cytogenet Cell Genet 93:1-10
• Schoch C et al (2002) Genes Chromosomes Cancer 35:20-29