XCE X/Yqh

XCyting Centromere Enumeration Probe

Order Number
D-0832-050-OG
Package Size
50 µl (5 Tests)
Labels
  
Chromosomes
XY
Regulatory Status
RUO

Product Description

XCE X/Yqh

The XCE X/Yqh DNA probe contains a mix of repetitive sequences specific for the chromosome X centromeric region in orange and chromosome Yqh in green which is located in the heterochromatic region at Yq12.

Please note that this product is not classified as an IVD product in the EU according to the REGULATION (EU) 2017/746 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 5 April 2017 on in vitro diagnostic medical devices and repealing Directive 98/79/EC and Commission Decision 2010/227/EU. It is marked as for ´Research Use Only´ (RUO).

Probe maps for selected products have been updated. These updates ensure a consistent presentation of all gaps larger than 10 kb including adjustments to markers, genes, and related elements. This update does not affect the device characteristics or product composition. Please refer to the list to find out which products now include updated probe maps.

Probe map details are based on UCSC Genome Browser GRCh37/hg19, with map components not to scale.

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Images

XCE X/Yqh

XCE X/Yqh hybridized to lymphocytes. One normal interphase and metaphase are shown.

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Expected Patterns

Expected Pattern 1

Normal Cell Female:
46, XX
Two orange (2O) signals.

Expected Pattern 2

Normal Cell Male:
46, XY
One green (1G) and one orange (1O) signal.

Expected Pattern 3

Aberrant Cell Female:
Turner (45,X0)
One orange (1O) signal.

Expected Pattern 4

Aberrant Cell Male:
Klinefelter (47,XXY)
One green (1G) and two orange (2O) signals.

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Literature

  • Dewald et al (1993) Bone Marrow Trans 12:149-154
  • Najfeld et al (1997) Bone Marrow Trans 19:829-834

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