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XL 22q11 IGL BA
Break Apart Probe
- Order Number
- D-5117-100-OG
- Package Size
- 100 µl (10 Tests)
- Chromosome
- 2222
- Regulatory Status
- IVDR
IVDR Certification
This probe is IVDR-certified in compliance with the Regulation (EU) 2017/746 for in vitro diagnostic medical devices (IVDR).
MetaSystems Probes has already certified a wide range of FISH probes, according to IVDR.
Please use the switch to change to the IVDD product.
IVDDIVDRDiscover all IVDR-certified productsDownload Instructions For Use (IFU)
Until further notice, we will continue to provide IVDD products in various countries.
As part of our phased rollout, the IVDR-certified probes are now available in Australia, Austria, Belgium, Croatia, Cyprus, Czech Republic, Estonia, France, Germany, Iceland, Italy, Kuwait, Lebanon, Liechtenstein, Luxembourg, Malta, Netherlands, New Zealand, Poland, Slovakia, Slovenia, South Africa, and Switzerland, with the list of countries continuously expanding.
The XL 22q11 IGL BA break-apart probe is a qualitative, non-automated test for the detection of IGL-rearrangements at 22q11.2 by fluorescence in situ hybridization (FISH). The product is intended as a diagnostic aid and assists in disease monitoring. The test population consists of patients with confirmed or suspected non-Hodgkin-lymphomas (NHL). Hybridization is to be performed on methanol/acetic-acid fixed cells derived from involved lymph node, involved bone marrow or other involved tissue.
The XL 22q11 IGL BA break-apart probe consists of an orange-labeled probe hybridizing proximal to the IGL gene region at 22q11.2 and a green-labeled probe hybridizing distal to the IGL gene region at 22q11.2.
Probe maps for selected products have been updated. These updates ensure a consistent presentation of all gaps larger than 10 kb including adjustments to markers, genes, and related elements. This update does not affect the device characteristics or product composition. Please refer to the list to find out which products now include updated probe maps.
Probe map details are based on UCSC Genome Browser GRCh37/hg19, with map components not to scale.
XL 22q11 IGL BA hybridized to normal lymphocytes. Two normal overlapping interphases are shown. The green and orange probes are flanking the IGVL gene region which is relatively large in size. Thus, the distance between the differently labeled signals in normal cells might appear greater than observed with probes flanking smaller genes.
Normal Cell:
Two green-orange colocalization/fusion signals (2GO).
Aberrant Cell (typical results):
One green-orange colocalization/fusion signal (1GO), one separate green (1G) and orange (1O) signal each resulting from a chromosome break in the respective locus.
Tumour Genetics Symposium 2025
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