XL 20q12/20qter/8cen plus

Deletion/Isochromosome/Enumeration Probe

Order Number
D-5122-100-TC
Package Size
100 µl (10 Tests)
Labels
   
Chromosomes
208
Regulatory Status
IVDR

IVDR Certification

This probe is IVDR-certified in compliance with the Regulation (EU) 2017/746 for in vitro diagnostic medical devices (IVDR).

MetaSystems Probes has already certified a wide range of FISH probes, according to IVDR.

Until further notice, we will continue to provide IVDD products in various countries.

As part of our phased rollout, the IVDR-certified probes are now available in Australia, Austria, Bangladesh, Belgium, Croatia, Cyprus, Czech Republic, Estonia, France, Germany, Iceland, Italy, Jordan, Kuwait, Lebanon, Liechtenstein, Luxembourg, Malta, Nepal, Netherlands, New Zealand, Oman, Palestine, Poland, Slovakia, Slovenia, South Africa, Switzerland, Ukraine, and United Arab Emirates with the list of countries continuously expanding.

Note: Our IVDR-certified XA probes are now available across all EU countries. For more details, please visit the individual product pages.

Intended Purpose

The XL 20q12/20qter/8cen plus probe is a qualitative, non-automated test for the detection of copy number variations of chromosome 8, deletions of the PTPRT gene region at 20q12 and isoderivative chromosomes 20q by fluorescence in situ hybridization (FISH). The product is intended as a diagnostic aid and assists in disease monitoring. The test population consists of patients with confirmed or suspected acute myeloid leukemia (AML), myelodysplastic neoplasms (MDS), myelodysplastic/myeloproliferative neoplasms (MDS/MPN) and myeloproliferative neoplasms (MPN). Hybridization is to be performed on methanol/acetic-acid fixed cells derived from bone marrow or peripheral blood.

Product Description

XL 20q12/20qter/8cen plus

The XL 20q12/20qter/8cen plus probe consists of an aqua-labeled probe hybridizing to the centromere of chromosome 8, an orange-labeled probe hybridizing to the PTPRT gene region at 20q12 and a green-labeled probe hybridizing to a region at 20q13.3.

Probe maps for selected products have been updated. These updates ensure a consistent presentation of all gaps larger than 10 kb including adjustments to markers, genes, and related elements. This update does not affect the device characteristics or product composition. Please refer to the list to find out which products now include updated probe maps.

Probe map details are based on UCSC Genome Browser GRCh37/hg19, with map components not to scale.

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Images

XL 20q12/20qter/8cen plus

XL 20q12/20qter/8cen plus hybridized to lymphocytes. One normal interphase is shown.

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Expected Patterns

Expected Pattern 1

Normal Cell:
Two blue (2B), two green (2G), and two orange (2O) signals.

Expected Pattern 2

Aberrant Cell (typical results):
Two blue (2B), two green (2G), and one orange (1O) signal resulting from the loss of one orange signal.

Expected Pattern 3

Aberrant Cell (typical results):
Three blue (3B), two green (2G) and one orange (1O) signal resulting from loss of one orange signal and a gain of the blue labeled chromosome.

Expected Pattern 4

Aberrant Cell (typical results):
Two blue (2B), three green (3G), and one orange (1O) signal resulting from the presence of ider(20q).

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