XCP-Mix #1O-#2G-#4GO

XCyting Chromosome Paint

Order Number
D-0328-200-MC
Package Size
200 µl (20 Tests)
Labels
  
Chromosomes
124

Description

XCP-Mix #1O-#2G-#4GO

Probe mix containing whole chromosome paints (XCP) specific for chromosome 1 labeled with an orange emitting fluorophore, chromosome 2 with a green emitting fluorophore, and chromosome 4 with a combination of the 2 fluorophores.

Probe map details based on UCSC Genome Browser GRCh37/hg19. Map components not to scale.

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Clinical Details

Ionizing radiation exposure gives rise to a variety of lesions in DNA that result in genetic instability and potentially tumorgenesis or cell death. At present, a particular interest of biological dosimetry is to establish a methodology to indicate interindividual sensitivity of people to ionising radiation. Current dose and risk estimates derived using cytogenetic methods and adequate calibration curves, are based on the assumption that all individuals respond equally to radiation. However, this is not necessarily the case. Individual increased radio sensitivity has been highly associated with susceptibility to cancer; therefore it is of particular interest to elucidate the mechanisms leading to such genetic changes.

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Images

XCP-Mix #1O-#2G-#4GO

XCP-Mix #1O-#2G-#4GO hybridized to lymphocytes. One normal metaphase is shown. XCP1 orange, XCP2, green and XCP 4 yellow (green-orange).

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Literature

  • Terzoudi et al (2006) Radiat Prot Disom 122:513-520
  • Pouzoulet et al (2007) J Radiat Res 48:425-434
  • Huber et al (2011) Radiat Oncol 6:doi:10.1186/1748-717X-6-32

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