About 100 guests from 36 countries met on the XVIII. MetaSystems Distributor Meeting (DM) in November to exchange experiences and to get to know new trends and developments at MetaSystems.
XL JAK2 BA
Break Apart Probe
- Order Number
- Package Size
- 100 µl (10 Tests)
The XL JAK2 BA is designed as a break apart probe with two probes juxtaposed and differently labeled. An orange labeled probe hybridizes proximal, and a green labeled probe hybridizes distal to the breakpoint in 9p24.
Probe map details based on UCSC Genome Browser GRCh37/hg19. Map components not to scale.
Patients with clinical characteristics of CML lacking a BCR/ABL fusion gene are usually referred to as having atypical CML. Most commonly diverse tyrosine kinase genes as the receptors FGFR1, PDGFRA, or PDGFRB are involved. In addition the Janus (tyrosine) kinases (JAK) can be deregulated in leukemia/lymphoma by copy number alterations, mutations and chromosomal translocations.
Chromosomal translocations targeting JAK2 are rare but recurrent abnormalities in myeloproliferative neoplasms, acute myeloid leukemia, acute lymphoblastic leukemia and lymphoma. In cell line models and primary patient material it could be shown that treatment with ruxolitinib has significant activity against JAK2 activated by gene rearrangement and presents evidence for potential activity against cells with JAK2 amplification.
- Chronic Myelogenous Leukemia and Myeloproliferative Neoplasms (CML/MPN)
- Acute Myelogenous Leukemia (AML)
- Acute Lymphoblastic Leukemia (ALL)
Two green-orange fusion signals (2GO).
Aberrant Cell (typical results):
One green (1G), one orange (1O), and one green-orange (1GO) fusion signal, indicating a chromosome break in the JAK2 locus.
- Bousquet et al (2005) Oncogene 24: 7248- 7252
- Chase et al (2012) Haematologica 93: 404- 408
- Ehrentraut et al (2013) PLOSone 8: e53767