The yearly MetaSystems Distributor Meeting (DM), brought into life in 2002 as a platform to gather all international partners of MetaSystems and other members of the global MetaSystems family, just ended last week. The DM is being organized in turns by MetaSystems Headquarters, MetaSystems USA (MGI), and MetaSystems Asia. Since MGI is celebrating its 25th anniversary in 2018 they decided to choose a special location: Nassau, The Bahamas!
Translocation/Dual Fusion Probe
- Order Number
- Package Size
- 100 µl
Chromosomal translocations affecting the IGH locus are recurrent in many types of lymphomas. The malignant transformation works via the juxtaposition of oncogenes next to regulatory sequences of the immunoglobulin locus.
The t(8;14)(q24;q32) MYC/IGH is the hallmark translocation of human Burkitt lymphoma where it accounts for about 85% of cases. The same translocation can be present in almost 5% of ALL patients and in diffuse large B-cell lymphomas. Although this aberration is often described to indicate a good prognosis, it can be an indicator of bad prognosis if associated with other factors, such as second aberrations like t(14;18) or BCL6 rearrangements.
- Non-Hodgkin Lymphomas (NHL)
- Acute Lymphoblastic Leukemia (ALL)
Two green (2G) and two orange signals (2O).
Aberrant Cell (typical results):
One green (1G), one orange (1O), and two green-orange fusion signals (2GO) resulting from a reciprocal translocation between the relevant loci.
- Siebert et al (1998) Blood 91:984-990
- Hummel et al (2006) N Engl J Med 354:2419-30
- Boerma et al (2009) Leukemia 23:225-234