XL CBFB/MYH11

Translocation/Dual Fusion Probe

Order Number
D-5022-100-OG
Package Size
100 µl
Labels
  
Chromosome
16

Description

XL CBFB/MYH11

This product has been replaced by the two products XL CBFB/MYH11 plus and XL CBFB. Order Numbers D-5126-100-OG and D-5092-100-OG

Clinical Details

Several recurrent balanced translocations and inversions, and their variants, are recognized in the WHO category acute myeloid leukemia (AML) with recurrent genetic abnormalities. Furthermore, several cytogenetic abnormalities are considered sufficient to establish the WHO diagnosis of AML with myelodysplasia-related features when 20% or more blood or marrow blasts are present.

The inv(16) and related t(16;16) are found in 10 % of all cases with de novo AML. In these rearrangements the core binding factor b (CBFB) gene on 16q22 is fused to the smooth muscle myosin heavy chain gene (MYH11) on 16p13.

Clinical Applications

  • Acute Myelogenous Leukemia (AML)

Images

XL CBFB/MYH11

XL CBFB/MYH11 was hybridized to normal lymphocytes. One interphases and one partial metaphase are shown.

Expected Patterns

Expected Pattern 1

Normal Cell:
Two green (2G) and two orange (2O) signals.

Expected Pattern 2

Aberrant Cell (typical results):
One green (1G), one orange (1O), and two green-orange colocalization/fusion signals (2GO) resulting from a reciprocal translocation between the respective loci.

Literature

  • Reijden et al (1999) Oncogene 8:543-550
  • Froehling et al (2002) J Clin Oncol 20:2480-2485
  • Doehner et al (2010) Blood 115:453-474

Downloads

Order Now or Request Assistance

Contact Us »

Contact MetaSystems directly or find your local MetaSystems partner.