The yearly MetaSystems Distributor Meeting (DM), brought into life in 2002 as a platform to gather all international partners of MetaSystems and other members of the global MetaSystems family, just ended last week. The DM is being organized in turns by MetaSystems Headquarters, MetaSystems USA (MGI), and MetaSystems Asia. Since MGI is celebrating its 25th anniversary in 2018 they decided to choose a special location: Nassau, The Bahamas!
Break Apart Probe
- Order Number
- Package Size
- 100 µl
Primary karyotypic changes in lymphoid neoplasms commonly juxtapose oncogenes to the potent transcriptional enhancers associated with IG and TCR loci in B and T cells, respectively, often resulting in elevated levels of protein expression and loss of normal mechanisms of control. Less commonly, fusion genes are created that encode novel hybrid proteins.
Variant translocations involving the IG kappa (IGK) locus in 2p11.2 or the IG lambda (IGL) locus in 22q11 occur recurrently in B-cell neoplasias. The different translocations involving immunoglobulin genes have a diagnostic value and can be used to monitor the clinical course of the disease.
- Non-Hodgkin Lymphomas (NHL)
Two green-orange (2GO) fusion signals.
Aberrant Cell (typical results):
One green-orange fusion signal (1GO) and one green (1G), one orange (1O) indicating a chromosome break in the IGK locus.
- Martin-Subero et al (2002) Int J Cancer 98:470-474
- Wlodarska et al (2004) Leukemia 10:1705-1710
- Einerson et al (2006) Leukemia 20:1790-1799