XL IGK

Break Apart Probe

Order Number
D-5034-100-OG
Package Size
100 µl
Labels
  
Chromosome
2

Description

XL IGK

This product has been replaced by XL 2p11 IGK BA. Order Number D-5116-100-OG

Clinical Details

Primary karyotypic changes in lymphoid neoplasms commonly juxtapose oncogenes to the potent transcriptional enhancers associated with IG and TCR loci in B and T cells, respectively, often resulting in elevated levels of protein expression and loss of normal mechanisms of control. Less commonly, fusion genes are created that encode novel hybrid proteins.

Variant translocations involving the IG kappa (IGK) locus in 2p11.2 or the IG lambda (IGL) locus in 22q11 occur recurrently in B-cell neoplasias. The different translocations involving immunoglobulin genes have a diagnostic value and can be used to monitor the clinical course of the disease.

Clinical Applications

  • Non-Hodgkin Lymphomas (NHL)

Images

XL IGK

XL IGK hybridized to lymphocytes. One normal partial metaphase is shown.

Expected Patterns

Expected Pattern 1

Normal Cell:
Two green-orange (2GO) fusion signals.

Expected Pattern 2

Aberrant Cell (typical results):
One green-orange fusion signal (1GO) and one green (1G), one orange (1O) indicating a chromosome break in the IGK locus.

Literature

  • Martin-Subero et al (2002) Int J Cancer 98:470-474
  • Wlodarska et al (2004) Leukemia 10:1705-1710
  • Einerson et al (2006) Leukemia 20:1790-1799

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