The yearly MetaSystems Distributor Meeting (DM), brought into life in 2002 as a platform to gather all international partners of MetaSystems and other members of the global MetaSystems family, just ended last week. The DM is being organized in turns by MetaSystems Headquarters, MetaSystems USA (MGI), and MetaSystems Asia. Since MGI is celebrating its 25th anniversary in 2018 they decided to choose a special location: Nassau, The Bahamas!
- Order Number
- Package Size
- 100 µl
The myelodysplastic syndromes and myeloproliferative disorders are associated with deregulated production of myeloid cells. According to WHO classification (2008) cytogenetic aberrations are observed in about 50 % of MDS cases. The most common aberrations are 5q-, 7/7q-, trisomy 8, del(20q), and inv(3) or t(3;3).
A chromosome 20q deletion is associated with about 5 % of primary MDS. The majority of cases has an interstitial deletion between 20q11.2 and q13.3. Isochromosome of the long arm of chromosome 20 with loss of interstitial material [ider(20q)] is a variant of deletion of chromosome 20q. Amplification of genes included in retained regions associated with loss of tumor suppressor genes in deleted regions could explain cell tumor progression and possibly the less favorable prognosis of ider(20q) compared with del(20q).
- Myelodysplastic Syndrome (MDS)
- Acute Myelogenous Leukemia (AML)
Normal Cell: Two green (2G) and two orange (2O) signals.
Aberrant Cell (typical results):
Two green (2G) and one orange (1O) signal, indicating a deletion in 20q12.
- Saunders et al (2005) Cancer Genet Cytogen 156:154-157
- Smoley et al (2006) Cancer Genet Cytogenet 173:144-149
- Douet-Gilbert et al (2008) Br J Haematol 143:716-720