The meeting of the German Society of Human Genetics (gfh) was held in Weimar, Germany this week and of course the attendees had the opportunity to visit the joined booth of MetaSystems and MetaSystems Probes. Main topics of the exhibition have been the latest advancements of the Neon case and imaging platform and RapidHyb, the revolutionary fast hybridization times of MetaSystems Probes' FISH probes.
- Order Number
- Package Size
- 100 µl (10 Tests)
An isochromosome of the long arm of chromosome 17, i(17q), is the most frequent genetic abnormality observed during the disease progression of Philadelphia chromosome positive chronic myeloid leukemia (CML). The breakpoints are located in the short arm of chromosome 17 within the Smith-Magenis critical region at 17p11. In neuroblastoma and other hematologic malignancies, amplification of 17q is a significant predictive factor for adverse outcome.
Isochromosome 17q, or i(17q), is ocurring in primitive neuroectodermal tumor/medulloblastoma (50 %), chronic myeloid leukemia (CML), acute myeloid leukemia (AML), and myelodysplastic syndrome (MDS).
- Chronic Myelogenous Leukemia (CML)
- Myelodysplastic Syndrome (MDS)
- Acute Lymphoblastic Leukemia (ALL)
Two green (2G) and two orange (2O) signals.
Aberrant Cell (typical result):
One green (1G) and three orange (3O) signals, indicating the presence of i(17q).
Aberrant Cell (typical results):
Two green (2G) and three orange (3O) signals, indicating a gain of 17q.
Aberrant Cells (typical results):
One green (1G) and two orange (2O) signals, indicating a deletion of the TP53 locus.
- Fioretos et al (1999) Blood 94:225-232
- Barbouti et al (2004) Am J Hum Genet 74:1 - 10
- Carvalho et al (2008) Genome Res 18:1724-1732