The XL MECOM 3q26 probe is designed as a break apart probe. Its orange labeled part hybridizes proximal to the MECOM gene locus at 3q26; the green labeled probe hybridizes to the distal gene region. MECOM stands for 'MDS1 and EVI1 complex locus'.
The myelodysplastic syndromes and myeloproliferative disorders are associated with deregulated production of myeloid cells. According to WHO classification (2008) cytogenetic aberrations are observed in about 50 % of MDS cases. The most common aberrations are 5q-, 7/7q-, trisomy 8, del(20q), and inv(3) or t(3;3).
Chromosomal translocations involving the EVI1 locus are a recurrent finding in myeloid leukemia and are associated with poor prognosis. Two common recurrent rearrangements affect the 3q26 locus. One is the inv(3)(q21q26) and the translocation t(3;3)(q21;q26), in which EVI1 overexpression is caused by juxtaposition of the EVI1 gene to enhancer elements of the Ribophorin gene at 3q21. EVI1 activation is also observed in the translocations t(3;12)(q26;p13) and t(3;21)(q26;q22) and is due to generation of the fusion genes ETV6/EVI1 and RUNX1/EVI1, respectively.
XL MECOM 3q26 hybridized to lymphocytes. One normal metaphase and one normal interphase are shown.
Normal Cell:
Two green-orange colocalization/fusion signals (2GO).
Aberrant Cell (typical results):
One green-orange colocalization/fusion signal (1GO), one separate green (1G) and orange (1O) signal each resulting from a chromosome break in the relevant locus.
Aberrant Cell (typical results):
Two green-orange colocalization/fusion signals (2GO) and one separate green (1G) signal indicating a chromosome break at a more distal region of the locus covered by the green probe.
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The yearly MetaSystems Distributor Meeting (DM), brought into life in 2002 as a platform to gather all international partners of MetaSystems and other members of the global MetaSystems family, just ended last week. The DM is being organized in turns by MetaSystems Headquarters, MetaSystems USA (MGI), and MetaSystems Asia. Since MGI is celebrating its 25th anniversary in 2018 they decided to choose a special location: Nassau, The Bahamas!
The first MetaSystems User Day took place in Altlussheim, Germany in the last week of September 2018. Approximately 25 guests took the opportunity to learn about the benefits of Neon, RapidScore, and the latest MetaSystems FISH probes.
MetaSystems attended the 2018 International Congress of Genetics being held in Foz do Iguacu, Brazil. The conference is known as one of the most important gatherings in the field of genetics in Latin America. Accordingly, the MetaSystems booth traffic was very busy. People from many Latin American countries took the opportunity to learn more about the latest MetaSystems products including Neon, Metafer, and the latest probes.
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