Upcoming Event in Netherlands from Mar 19 to Mar 21, 2025
XL del(7)(q22q31)
Deletion Probe
- Order Number
- D-5068-100-TC
- Package Size
- 100 µl (10 Tests)
- Chromosome
- 077
- Regulatory Status
- IVDD
IVDR Certification
This probe is IVDR-certified in compliance with the Regulation (EU) 2017/746 on in vitro diagnostic medical devices (IVDR).
MetaSystems Probes has already certified a wide range of FISH probes, according to IVDR.
This product remains IVDD-certified until further notice.
XL del(7)(q22q31) consists of an orange-labeled probe hybridizing to the KMT2E gene region at 7q22, a green-labeled probe hybridizing to the MET gene region at 7q31.2 and an aqua-labeled probe hybridizing to the centromere of chromosome 7.
Probe maps for selected products have been updated. These updates ensure a consistent presentation of all gaps larger than 10 kb including adjustments to markers, genes, and related elements. This update does not affect the device characteristics or product composition. Please refer to the list to find out which products now include updated probe maps.
Probe map details are based on UCSC Genome Browser GRCh37/hg19, with map components not to scale.
Clinical Applications
- Myelodysplastic Syndrome (MDS)
- Acute Myelogenous Leukemia (AML)
XL del(7)(q22q31) hybridized to lymphocytes. Two normal interphases are shown.
Normal Cell:
Two Blue (2B), two green (2G) and two orange (2O) signals.
Aberrant Cell (typical results):
Two green (2G), one orange (1O), and 2 blue (2B) signals indicating the deletion of a 7q22 locus or one green (1G), two orange (2O),and 2 blue (2B) signals, indicating the deletion of a 7q31 locus.
Aberrant Cell (typical results):
Two blue (2B),one green (1G) and one orange (1O) signal resulting from the loss of one green and one orange signal.
Aberrant Cell (typical results):
One blue (1B), one green (1G) and one orange (1O) signal resulting from the loss of one chromosome.
- LeBeau et al (1996) Blood 88:1930-1935
- Emerling et al (2002) Oncogene 21:4849-4854
- De Weer et al (2010) PLoS One 13:e8676
Package Insert (EN)Package Insert (IT)Performance Data (English)Probes Catalog
Certificate of Analysis (CoA)
or go to CoA DatabaseOur Complete Set of XA Aneusomy Probes for Prenatal Testing Is IVDR Certified.
MetaSystems Probes has received IVDR certification for our XCyting FISH probes for prenatal aneusomy testing – the XA aneusomy probes.
Feb 1, 2025: Rollout of IVDR-certified XCyting FISH Probes!
The first phase of this rollout includes the following countries: Austria, Cyprus, Estonia, Germany, Iceland and The Netherlands. More countries will be supplied over time.
