XL del(7)(q22q31)

Deletion Probe

Order Number: D-5068-100-TC

Package Size: 100 µl (10 Tests)

Labels: orange green blue

Chromosome: 077

Regulatory Status: IVDD

XL del(7)(q22q31)

Deletion Probe

Order Number: D-5068-100-TC

Package Size: 100 µl (10 Tests)

Labels: orange green blue

Chromosome: 077

Regulatory Status: IVDD

IVDR Certification

This probe is IVDR-certified in compliance with the Regulation (EU) 2017/746 on in vitro diagnostic medical devices (IVDR).

MetaSystems Probes has already certified a wide range of FISH probes, according to IVDR.

This product remains IVDD-certified until further notice.

Please use the switch to change to the IVDR product.

IVDD IVDR Discover all IVDR-certified products

Product Description

XL del(7)(q22q31) consists of an orange-labeled probe hybridizing to the KMT2E gene region at 7q22, a green-labeled probe hybridizing to the MET gene region at 7q31.2 and an aqua-labeled probe hybridizing to the centromere of chromosome 7.

Probe maps for selected products have been updated. These updates ensure a consistent presentation of all gaps larger than 10 kb including adjustments to markers, genes, and related elements. This update does not affect the device characteristics or product composition. Please refer to the list to find out which products now include updated probe maps.

Probe map details are based on UCSC Genome Browser GRCh37/hg19, with map components not to scale.

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Clinical Details

Clinical Applications

Myelodysplastic Syndrome (MDS)
Acute Myelogenous Leukemia (AML)

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Images

XL del(7)(q22q31) hybridized to lymphocytes. Two normal interphases are shown.

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Expected Patterns

Normal Cell:
Two Blue (2B), two green (2G) and two orange (2O) signals.

Aberrant Cell (typical results):
Two green (2G), one orange (1O), and 2 blue (2B) signals indicating the deletion of a 7q22 locus or one green (1G), two orange (2O),and 2 blue (2B) signals, indicating the deletion of a 7q31 locus.