The yearly MetaSystems Distributor Meeting (DM), brought into life in 2002 as a platform to gather all international partners of MetaSystems and other members of the global MetaSystems family, just ended last week. The DM is being organized in turns by MetaSystems Headquarters, MetaSystems USA (MGI), and MetaSystems Asia. Since MGI is celebrating its 25th anniversary in 2018 they decided to choose a special location: Nassau, The Bahamas!
- Order Number
- Package Size
- 100 µl
The XL del(7)(q22q31) locus-specific probe detects deletions in the long arm of chromosome 7. The orange labeled probe hybridizes to a specific region at 7q22 including the KMT2E (formerly MLL5) gene. The green labeled probe hybridizes specifically to 7q31 and includes the MET proto-oncogene. A blue (aqua) labeled probe which hybridizes to the centromere of chromosome 7 functions as a reference probe.
The myelodysplastic syndromes and myeloproliferative disorders are associated with deregulated production of myeloid cells. According to WHO classification (2008) cytogenetic aberrations are observed in about 50 % of MDS cases. The most common aberrations are 5q-, 7/7q-, trisomy 8, del(20q), and inv(3) or t(3;3).
Partial or complete deletion of chromosome 7 is a common finding in MDS and AML. At least three distinct regions of common deletions have been identified: the band 7q22 and the more telomeric regions 7q31-32 and 7q36. In most studies monosomy 7/del 7q indicates as an isolated abnormality a significantly worse prognosis.
- Myelodysplastic Syndrome (MDS)
- Acute Myelogenous Leukemia (AML)
Two green (2G), two orange (2O), and two blue (2B) signals.
Aberrant Cell (typical results):
Two green (2G), one orange (1O), and 2 blue (2B) signals indicating the deletion of a 7q22 locus or one green (1G), two orange (2O), and 2 blue (2B) signals, indicating the deletion of a 7q31 locus.
Aberrant Cell (typical results): One green (1G), one orange (1O), and two blue (2B) signals indicating the deletion of a 7q22 locus and of a 7q31 locus.
Aberrant Cell (typical results): One green (1G), one orange (1O), and one blue (1B) signal indicating a monosomy 7.
- LeBeau et al (1996) Blood 88:1930-1935
- Liang et al (1998) Proc Natl Acad Sci USA 95:3781-3785
- Haase D (2008) Ann Hematol 87:515-526