XL CCND1 consists of an orange-labeled probe hybridizing proximal to the MYEOV gene region at 11q13.3 and a green-labeled probe hybridizing to CCND1 and distal to the CCND1 gene region at 11q13.3.

Probe maps are created in accordance with the intended purpose of the product. Solid colored bars do not necessarily indicate that the probe fully covers the indicated genomic region. Therefore, caution is advised when interpreting results generated through off-label use. Probe map details based on UCSC Genome Browser GRCh37/hg19. Map components not to scale. Further information is available on request.

The t(11;14)(q13;q32) chromosomal translocation is the hallmark of mantle cell lymphoma (MCL) and is found in approximately 30% of multiple myeloma (MM) tumors with a 14q32 translocation. Variant translocations can fuse CCND1 with other genes, such as IGK or IGL.

Clinical Applications

• Multiple Myeloma and Plasma Cell Neoplasms (MM)
• Non-Hodgkin Lymphomas (NHL)
• Chronic Lymphocytic Leukemia (CLL)

XL CCND1 hybridized to lymphocytes. One normal metaphase and two normal interphases are shown.

• Vandraager et al (1997) Blood 89:349-350
• Fonseca et al (2002) Blood 99:3735-3741
• Wlodarska et al (2004) Leukemia 18:1705-1710

• Utility and performance of bacterial artificial chromosomes-on-beads assays in chromosome analysis of clinical prenatal samples, products of conception and blood samples.
• A child with multiple congenital anomalies due to partial trisomy 7q22.1 → qter resulting from a maternally inherited balanced translocation: a case report and review of literature.
• Distinct roles of ATM and ATR in the regulation of ARP8 phosphorylation to prevent chromosome translocations.
• Heterogeneous MYCN amplification in neuroblastoma: a SIOP Europe Neuroblastoma Study.
• Immense random colocalization, revealed by automated high content image cytometry, seriously questions FISH as gold standard for detecting EML4-ALK fusion.
• Fluorescence in situ hybridisation assays designed for del(7q) detection uncover more complex rearrangements in myeloid leukaemia cell lines
• Detection of t(7;12)(q36;p13) in paediatric leukaemia using dual colour fluorescence in situ hybridisation.
• A rare case of t(11;22) in a mantle cell lymphoma like B-cell neoplasiaresulting in a fusion of IGL and CCND1: case report.
• Genomic DNA-chip hybridization in t(11;14)-positive mantle cell lymphomas shows a high frequency of aberrations and allows a refined characterization of consensus regions.