About 100 guests from 36 countries met on the XVIII. MetaSystems Distributor Meeting (DM) in November to exchange experiences and to get to know new trends and developments at MetaSystems.
Break Apart Probe
- Order Number
- Package Size
- 100 µl (10 Tests)
XL CCND1 consists of an orange-labeled probe hybridizing proximal to the MYEOV gene region at 11q13.3 and a green-labeled probe hybridizing to CCND1 and distal to the CCND1 gene region at 11q13.3.
Probe maps are created in accordance with the intended purpose of the product. Solid colored bars do not necessarily indicate that the probe fully covers the indicated genomic region. Therefore, caution is advised when interpreting results generated through off-label use. Probe map details based on UCSC Genome Browser GRCh37/hg19. Map components not to scale. Further information is available on request.
The t(11;14)(q13;q32) chromosomal translocation is the hallmark of mantle cell lymphoma (MCL) and is found in approximately 30% of multiple myeloma (MM) tumors with a 14q32 translocation. Variant translocations can fuse CCND1 with other genes, such as IGK or IGL.
- Multiple Myeloma and Plasma Cell Neoplasms (MM)
- Non-Hodgkin Lymphomas (NHL)
- Chronic Lymphocytic Leukemia (CLL)
Two green-orange (2GO) fusion signals representing the two normal CCND1 loci.
Aberrant Cell (typical results):
One green (1G), one orange (1O), and one green-orange (1GO) fusion signal, indicating a chromosome break in the CCND1 locus.
- Vandraager et al (1997) Blood 89:349-350
- Fonseca et al (2002) Blood 99:3735-3741
- Wlodarska et al (2004) Leukemia 18:1705-1710