XL CCND1

Break Apart Probe

Order Number
D-5071-100-OG
Package Size
100 µl
Labels
  
Chromosome
11

Description

XL CCND1

The XL CCND1 probe is designed as a break apart probe. Its orange labeled part hybridizes proximal to CCND1 (BCL1) and the MYEOV gene at 11q13; the green labeled probe hybridizes to the distal region of CCND1.

Clinical Details

The t(11;14)(q13;q32) chromosomal translocation is the hallmark of mantle cell lymphoma (MCL) and is found in approximately 30 % of multiple myeloma (MM) tumors with a 14q32 translocation. Variant translocations can fuse CCND1 also with other genes, such as IGK or IGL.

Clinical Applications

  • Multiple Myeloma and Plasma Cell Neoplasms (MM)
  • Non-Hodgkin Lymphomas (NHL)

Images

XL CCND1

XL CCND1 hybridized to lymphocytes. One normal metaphase and two normal interphases are shown.

Expected Patterns

Expected Pattern 1

Normal Cell:
Two green-orange (2GO) fusion signals representing the two normal CCND1 loci.

Expected Pattern 2

Aberrant Cell (typical results):
One green (1G), one orange (1O), and one green-orange (1GO) fusion signal, indicating a chromosome break in the CCND1 locus.

Literature

  • Vandraager et al (1997) Blood 89:349-350
  • Fonseca et al (2002) Blood 99:3735-3741
  • Wlodarska et al (2004) Leukemia 18:1705-1710

Downloads

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