XL t(14;16)

Translocation/Dual Fusion Probe

Order Number
D-5072-100-OG
Package Size
100 µl
Labels
  
Chromosomes
1416

Description

XL t(14;16)

This product has been replaced by XL t(14;16) IGH/MAF DF. Order Number D-5112-100-OG

Clinical Details

Genetic aberrations present in multiple myeloma cells play a significant role in the risk stratification and therapeutic approach in multiple myeloma patients. Chromosomal translocations affecting the IGH locus are recurrent in many types of leukemias and lymphomas. The malignant transformation works via the juxtaposition of oncogenes next to regulatory sequences of the immunoglobulin locus.

The t(14;16) is found in 5-7 % of all MM cases. The presence of t(14;16) has been associated with more aggressive disease and shorter survival among patients treated with either conventional or high-dose chemotherapy.

Clinical Applications

  • Multiple Myeloma and Plasma Cell Neoplasms (MM)

Images

XL t(14;16)

XL t(14;16) hybridized to lymphocytes. One normal metaphase and one normal interphase are shown.

Expected Patterns

Expected Pattern 1

Normal Cell:
Two green (2G) and two orange signals (2O).

Expected Pattern 2

Aberrant Cell (typical results):
One green (1G), one orange (1O), and two green-orange fusion signals (2GO).

Literature

  • Chesi et al (2000) Ann Onco 11:131-135
  • Fonseca et al (2003) Blood 101:4569-4575
  • Kumar et al (2009) Mayo Clin Proc 84:1095-1110

Downloads

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