XL NUP98 consists of an orange-labeled probe hybridizing proximal to the NUP98 gene region at 11p15.4 and a green-labeled probe hybridizing distal to the NUP98 gene region at 11p15.4.

Probe maps for selected products have been updated. These updates ensure a consistent presentation of all gaps larger than 10 kb including adjustments to markers, genes, and related elements. This update does not affect the device characteristics or product composition. Please refer to the list to find out which products now include updated probe maps.

Probe map details are based on UCSC Genome Browser GRCh37/hg19, with map components not to scale.

Several recurrent balanced translocations and inversions, and their variants, are recognized in the WHO category acute myelogenous leukemia (AML) with recurrent genetic abnormalities. Furthermore, several cytogenetic abnormalities are considered sufficient to establish the WHO diagnosis of AML with myelodysplasia-related features if 20% or more blood or marrow blasts are present.

Translocations involving nucleoporin 98kD (NUP98) on chromosome 11p15 occur at relatively low frequency in AML, but can be missed with routine karyotyping. NUP98 is known to be fused to at least 28 different partner genes in patients with hematopoietic malignancies, including acute myeloid leukemia, chronic myeloid leukemia in blast crisis, myelodysplastic syndrome, acute lymphoblastic leukemia, and bilineage/biphenotypic leukemia.

Clinical Applications

• Acute Myelogenous Leukemia (AML)
• Acute Lymphoblastic Leukemia (ALL)
• Myelodysplastic Syndrome (MDS)

XL NUP98 was hybridized to lymphocytes. One normal interphase is shown.

• Nebral et al (2005) Haematologica 90:746-752
• Romana et al (2006) Leukemia 20:696-706
• Gough et al (2011) Blood 118:6247-6257