The meeting of the German Society of Human Genetics (gfh) was held in Weimar, Germany this week and of course the attendees had the opportunity to visit the joined booth of MetaSystems and MetaSystems Probes. Main topics of the exhibition have been the latest advancements of the Neon case and imaging platform and RapidHyb, the revolutionary fast hybridization times of MetaSystems Probes' FISH probes.
Break Apart Probe
- Order Number
- Package Size
- 100 µl (10 Tests)
Several recurrent balanced translocations and inversions, and their variants, are
recognized in the WHO category AML with recurrent genetic abnormalities. Furthermore, several cytogenetic abnormalities are considered sufficient to establish the WHO diagnosis of AML with myelodysplasia-related features when 20% or more blood or marrow blasts are present.
Translocations involving nucleoporin 98kD (NUP98) on chromosome 11p15 occur at relatively low frequency in acute myeloid leukemia (AML), but can be missed with routine karyotyping. NUP98 is known to be fused to at least 28 different partner genes
in patients with hematopoietic malignancies, including acute myeloid leukemia, chronic
myeloid leukemia in blast crisis, myelodysplastic syndrome, acute lymphoblastic
leukemia, and bilineage/biphenotypic leukemia.
- Acute Myelogenous Leukemia (AML)
- Acute Lymphoblastic Leukemia (ALL)
- Myelodysplastic Syndrome (MDS)
Two green-orange fusion signals (2GO).
Aberrant Cell (typical results):
One green (1G), one orange (1O), and one green-orange (1GO) fusion signal, indicating a chromosome break in the NUP98 locus.
- Nebral et al (2005) Haematologica 90: 746- 752
- Romana et al (2006) Leukemia 20: 696-706
- Gough et al (2011) Blood 118: 6247-6257