About 100 guests from 36 countries met on the XVIII. MetaSystems Distributor Meeting (DM) in November to exchange experiences and to get to know new trends and developments at MetaSystems.

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XL 5q31/5q33/5p15 consists of an aqua-labeled probe hybridizing to a region at 5p15.2-15.3, an orange-labeled probe hybridizing to the EGR1 gene region at 5q31.2 and a green-labeled probe hybridizing to the RPS14 gene region at 5q32-33.1.
Probe maps are created in accordance with the intended purpose of the product. Solid colored bars do not necessarily indicate that the probe fully covers the indicated genomic region. Therefore, caution is advised when interpreting results generated through off-label use. Probe map details based on UCSC Genome Browser GRCh37/hg19. Map components not to scale. Further information is available on request.
Myelodysplastic syndromes (MDS) and myeloproliferative disorders are associated with deregulated production of myeloid cells. According to WHO classification (2008), cytogenetic aberrations are observed in about 50% of MDS cases. The most common aberrations are 5q-, 7/7q-, trisomy 8, del(20q), and inv(3) or t(3,3).
5q syndrome is defined as a primary MDS with del(5q) as the sole karyotypic abnormality. Two different critical regions are described, one is located at 5q31 and contains the EGR1 and CDC25C genes. A more distal region at 5q32-q33 containing RPS14 has been identified as a causal region for 5q syndrome.
Normal Cell:
Two green (2G), two orange (2O) and two blue (2B) signals.
Aberrant Cell (typical results):
One green (1G), one orange (1O), and two blue (2B) signals indicating the deletion of a 5q33 locus and of a 5q31 locus.
Aberrant Cell (typical results):
Two green (2G), one orange (1O), and two blue (2B) signals indicating the deletion of a 5q31 locus or one green (1G), two orange (2O), and 2 blue (2B) signals, indicating the deletion of a 5q33 locus.
Aberrant Cell (typical results):
One green (1G), one orange (1O), and one blue (1B) signal indicating a monosomy 5.
Certificate of Analysis (CoA)
or go to CoA Database