XL 5p15/9q22/15q22 Hyperdiploidy

Enumeration Probe

Order Number
Package Size
100 µl (10 Tests)


XL 5p15/9q22/15q22 Hyperdiploidy

The XL 5p15/9q22/15q22 Hyperdiploidy probe is designed as a triple color assay and allows enumeration of chromosomes 5, 9 and 15. A green labeled probe hybridizes to a region at 5p15, a blue one to the 9q22 region, and an orange one to the 15q22 region.

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Clinical Details

In multiple myeloma (MM) pathogenesis hyperdiploidy and non-hyperdiploidy are recognized as two major cytogenetic pathways. The hyperdiploid group is characterized by gains of the odd chromosomes 3, 5, 7, 9, 11, 15, 19, and 21. Hyperdiploidy has been internationally defined and requires trisomy for at least 2 of the 3 chromosomes 5, 9, and 15.

Patients with hyperdiploid multiple myeloma, which can be observed in 50-60% of patients, tend to have a better prognosis than those with a non-hyperdiploid subtype.

Clinical Applications

  • MM
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XL 5p15/9q22/15q22 Hyperdiploidy

XL 5p15/9q22/15q22 hybridized to lymphocytes. Two normal interphases are shown.

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Expected Patterns

Expected Pattern 1

Normal Cell:
Two green (2G), two blue (2B), and two orange (2O) signals.

Expected Pattern 2

Aberrant Cell (typical results):
Three green (3G), two blue (2B), and three orange (3O) signals, indicating hyperdiploidy.

Expected Pattern 3

Aberrant Cell (typical results):
Two green (2G), three blue (3B), and three orange (3O) signals, indicating hyperdiploidy.

Expected Pattern 4

Aberrant Cell (typical results):
Three green (3G), three blue (3B), and two orange (2O) signals, indicating hyperdiploidy.

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  • Wuilleme et al (2005) Leukemia 19:275-278
  • Kumar et al (2009) Mayo Clin Proc. 84:1095-1110
  • Bochtler et al (2011) Blood 117:3809-3815