XL CDKN2C/CKS1B

Amplification/Deletion Probe

Order Number
D-5099-100-OG
Package Size
100 µl
Labels
  
Chromosome
1

Description

XL CDKN2C/CKS1B

The XL CDKN2C/CKS1B locus-specific probe detects deletions or amplifications in the long and short arm of chromosome 1. The orange labeled probe hybridizes to a specific region at 1q21 including the CKS1B gene. The green labeled probe hybridizes specifically to 1p32 and includes the CDKN2C (p18) gene.

Clinical Details

Multiple myeloma (MM) is a plasma cell malignancy characterized by very complex cytogenetic and molecular genetic aberrations. Hyperdiploid karyotypes are characterized mainly by trisomies of chromosomes 3, 5, 7, 9, 11, 15, 19, and 21, non-hyperdiploid karytoypes typically have translocations involving the IGH locus at 14q32. The most frequent deletions are 13q, 17p and 1p32.

Deletions of chromosome 1p have been described in 7 % to 15 % of cases of myeloma with inconsistent clinical consequences. CDKN2C at 1p32.3 has been identified in myeloma cell lines as the potential target of the deletion. Gain of 1q is one of the most recurrent chromosomal aberrations in MM. Amplification and overexpression of the CKS1B gene in chromosome band 1q21 has been associated with an aggressive clinical course in multiple myeloma.

Clinical Applications

  • Multiple Myeloma and Plasma Cell Neoplasms (MM)

Images

XL CDKN2C/CKS1B

XL CDKN2C/CKS1B hybridized to lymphocytes. Three normal interphases are shown.

Expected Patterns

Expected Pattern 1

Normal Cell:
Two green (2G) and two orange (2O) signals.

Expected Pattern 2

Aberrant Cell (typical results):
Two green (2G) and three orange (3O) signals resulting from gain of one orange signal.

Expected Pattern 3

Aberrant Cell (typical results):
One green (1G) and two orange (2O) signal resulting from loss of one green signal.

Literature

  • Hanamura et al (2006), Blood 108 :1724-1732
  • Leone et al (2008) Clin Cancer Res 14:6033-6041
  • Jian et al (2016) Medicine 95 :1-7

Downloads

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