Fluorescence in situ hybridization has become an essential detection assay in today´s routine diagnostics. However, long hybridization times of many hours to overnight are still a restrictive factor. We have refined the production process of our FISH probes to reduce background and artefacts and to improve the signal to noise ratio, particularly in short-time hybridization. Since mid-2015, one hour hybridization on lymphocytes is an integral part of quality control for all XCyting locus-specific probes at our manufacturing facility.
- Order Number
- Package Size
- 100 µl
TP53 is described as 'the guardian of the genome' because of its role in conserving stability by preventing genome mutation. Therefore TP53 is classified as a tumor suppressor gene. It has many mechanisms of anticancer function, and plays a role in apoptosis, genomic stability, and inhibition of angiogenesis. If the TP53 gene is damaged tumor suppression is severely reduced.
The TP53 gene is located on the short arm of chromosome 17 (17p13.1). More than 50 % of human tumors contain either a mutation or deletion of the TP53 gene.
- Chronic Lymphocytic Leukemia (CLL)
- Multiple Myeloma and Plasma Cell Neoplasms (MM)
- Chronic Myelogenous Leukemia (CML)
Two green (2G) and two orange (2O) signals.
Aberrant Cell (typical results):
Two green (2G) and one orange (1O) signal resulting from loss of one orange signal.
- Drach et al (1998) Blood 92:802-809
- Gunn at al (2008) J Mol Diagn 10:442-451
- Neben et al (2013) J Clin Oncol 31:4325-4332