XL TP53/17cen

Deletion Probe

Order Number
D-5103-100-OG
Package Size
100 µl
Labels
  
Chromosome
17

Description

XL TP53/17cen

The XL TP53/17cen probe detects deletions which occur in 17p13 and which involve the TP53 locus. The specific probe is labeled in orange while a green labeled probe which hybridizes to the centromere of chromosome 17 functions as a reference probe.

Clinical Details

TP53 is described as 'the guardian of the genome' because of its role in conserving stability by preventing genome mutation. Therefore TP53 is classified as a tumor suppressor gene. It has many mechanisms of anticancer function, and plays a role in apoptosis, genomic stability, and inhibition of angiogenesis. If the TP53 gene is damaged tumor suppression is severely reduced.

The TP53 gene is located on the short arm of chromosome 17 (17p13.1). More than 50 % of human tumors contain either a mutation or deletion of the TP53 gene.

Clinical Applications

  • Chronic Lymphocytic Leukemia (CLL)
  • Multiple Myeloma and Plasma Cell Neoplasms (MM)
  • Chronic Myelogenous Leukemia (CML)

Images

XL TP53/17cen

XL TP53/17cen hybridized to lymphocytes. Two normal interphases are shown.

Expected Patterns

Expected Pattern 1

Normal Cell:
Two green (2G) and two orange (2O) signals.

Expected Pattern 2

Aberrant Cell (typical results):
Two green (2G) and one orange (1O) signal resulting from loss of one orange signal.

Literature

  • Drach et al (1998) Blood 92:802-809
  • Gunn at al (2008) J Mol Diagn 10:442-451
  • Neben et al (2013) J Clin Oncol 31:4325-4332

Downloads

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