The meeting of the German Society of Human Genetics (gfh) was held in Weimar, Germany this week and of course the attendees had the opportunity to visit the joined booth of MetaSystems and MetaSystems Probes. Main topics of the exhibition have been the latest advancements of the Neon case and imaging platform and RapidHyb, the revolutionary fast hybridization times of MetaSystems Probes' FISH probes.
- Order Number
- Package Size
- 100 µl (10 Tests)
TP53 is described as 'the guardian of the genome' because of its role in conserving stability by preventing genome mutation. Therefore TP53 is classified as a tumor suppressor gene. It has many mechanisms of anticancer function, and plays a role in apoptosis, genomic stability, and inhibition of angiogenesis. If the TP53 gene is damaged tumor suppression is severely reduced.
The TP53 gene is located on the short arm of chromosome 17 (17p13.1). More than 50 % of human tumors contain either a mutation or deletion of the TP53 gene.
- Chronic Lymphocytic Leukemia (CLL)
- Multiple Myeloma and Plasma Cell Neoplasms (MM)
- Chronic Myelogenous Leukemia (CML)
Two green (2G) and two orange (2O) signals.
Aberrant Cell (typical results):
Two green (2G) and one orange (1O) signal resulting from loss of one orange signal.
- Drach et al (1998) Blood 92:802-809
- Gunn at al (2008) J Mol Diagn 10:442-451
- Neben et al (2013) J Clin Oncol 31:4325-4332