The XL 5q32 PDGFRB BA probe is designed as a break apart probe. The orange labeled probe hybridizes proximal to the breakpoint in the PDGFRB gene region at 5q32, the green labeled probe hybridizes distal to the breakpoint.
The updated (2016) World Health Organization (WHO) classification of tumors of the hematopoietic and lymphoid tissues indicates the category myeloid/lymphoid neoplasms with eosinophilia and rearrangement of PDGFRA, PDGFRB, FGFR1, or with PCM1-JAK2.
Myeloid neoplasms (MPNs) with rearrangement of PDGFRB are phenotypically and genotypically diverse. The fusion genes involving PDGFRB described to date have been associated with cytogenetically detectable translocations. MPNs associated with rearrangement of PDGFRB are responsive to Imatinib.
XL 5q32 PDGFRB BA hybridized to lymphocytes. Three normal interphases are shown.
Normal Cell:
Two green-orange colocalization/fusion signals (2GO).
Aberrant Cell (typical results):
One green-orange colocalization/fusion signal (1GO), one separate green (1G) and orange (1O) signal each resulting from a chromosome break in the relevant locus.
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The yearly MetaSystems Distributor Meeting (DM), brought into life in 2002 as a platform to gather all international partners of MetaSystems and other members of the global MetaSystems family, just ended last week. The DM is being organized in turns by MetaSystems Headquarters, MetaSystems USA (MGI), and MetaSystems Asia. Since MGI is celebrating its 25th anniversary in 2018 they decided to choose a special location: Nassau, The Bahamas!
The first MetaSystems User Day took place in Altlussheim, Germany in the last week of September 2018. Approximately 25 guests took the opportunity to learn about the benefits of Neon, RapidScore, and the latest MetaSystems FISH probes.
MetaSystems attended the 2018 International Congress of Genetics being held in Foz do Iguacu, Brazil. The conference is known as one of the most important gatherings in the field of genetics in Latin America. Accordingly, the MetaSystems booth traffic was very busy. People from many Latin American countries took the opportunity to learn more about the latest MetaSystems products including Neon, Metafer, and the latest probes.
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