The meeting of the German Society of Human Genetics (gfh) was held in Weimar, Germany this week and of course the attendees had the opportunity to visit the joined booth of MetaSystems and MetaSystems Probes. Main topics of the exhibition have been the latest advancements of the Neon case and imaging platform and RapidHyb, the revolutionary fast hybridization times of MetaSystems Probes' FISH probes.
Break Apart Probe
- Order Number
- Package Size
- 100 µl (10 Tests)
Chromosomal aberrations with breakpoints in T-cell receptor (TCR) gene loci are recurrent in several T-cell malignancies. The chromosomal alterations juxtapose oncogenes next to TCR regulatory sequences leading to deregulated expression of those oncogenes.
T-cell prolymphocytic leukemia (T-PLL) harbors frequent alterations of the TCRA/D locus, usually caused by an inv(14)(q11q32). By molecular cytogenetics studies, the incidence of TCRA/D rearrangements is about 24% of all T-ALL cases.
- Acute Lymphoblastic Leukemia (ALL)
- Non-Hodgkin Lymphomas (NHL)
Two green-orange fusion signals (2GO).
Aberrant Cell (typical results):
One green (1G), one orange (1O), and one green-orange (1GO) fusion signal, indicating a chromosome break in the TCRA/D locus.
- Gesk et al (2003) Leukemia 17: 738-745
- Leich et al (2007) J Pathol 213: 99-105
- Feldman et al (2009) Am J Clin Pathol 130: 178-185