XL TCRA/D

Break Apart Probe

Order Number
D-5106-100-OG
Package Size
100 µl
Labels
  
Chromosome
14

Description

XL TCRA/D

The XL TCRA/D is designed as break apart probe. An orange labeled probe covers the region proximal to TCRA/D at 14q11, and a green labeled probe covers the region distal to the TCRA/D gene.

Clinical Details

Chromosomal aberrations with breakpoints in T-cell receptor (TCR) gene loci are recurrent in several T-cell malignancies. The chromosomal alterations juxtapose oncogenes next to TCR regulatory sequences leading to deregulated expression of those oncogenes.

T-cell prolymphocytic leukemia (T-PLL) harbors frequent alterations of the TCRA/D locus, usually caused by an inv(14)(q11q32). By molecular cytogenetics studies, the incidence of TCRA/D rearrangements is about 24% of all T-ALL cases.

Clinical Applications

  • Acute Lymphoblastic Leukemia (ALL)
  • Non-Hodgkin Lymphomas (NHL)

Images

XL TCRA/D

XL TCRA/D hybridized to lymphocytes. One normal metaphase is shown.

Expected Patterns

Expected Pattern 1

Normal Cell:
Two green-orange fusion signals (2GO).

Expected Pattern 2

Aberrant Cell (typical results):
One green (1G), one orange (1O), and one green-orange (1GO) fusion signal, indicating a chromosome break in the TCRA/D locus.

Literature

  • Gesk et al (2003) Leukemia 17: 738-745
  • Leich et al (2007) J Pathol 213: 99-105
  • Feldman et al (2009) Am J Clin Pathol 130: 178-185

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