XL MYC amp

Amplification Probe

Order Number
D-6008-100-OG
Package Size
100 µl
Labels
  
Chromosome
8

Description

XL MYC amp

The XL MYC amp probe detects amplifications in the long arm of chromosome 8. The orange labeled probe is designed to hybridize to the MYC locus at 8q24. A green labeled probe hybridizes to the 8cen region and functions as a control probe.

This probe is intended for methanol/acetic-acid fixed cells and tissue sections.

Clinical Details

Amplification of MYC has been described in many types of tumor, including breast, cervical and colon cancers, as well as in squamous cell carcinomas of the head and neck, myeloma, non-Hodgkin's lymphoma, gastric adenocarcinomas and ovarian cancer. MYC is the most frequently amplified oncogene and the elevated expression of its gene product correlates with tumor aggression and poor clinical outcome.

The proto-oncogene MYC, located at 8q24.1, encodes a nuclear phosphoprotein transcription factor that has an integral role in a variety of cellular processes, such as cell cycle progression, proliferation, metabolism, adhesion, differentiation, and apoptosis.

Clinical Applications

  • Solid Tumors (Solid Tumors)

Images

XL MYC amp

XL MYC amp hybridized to breast cancer tissue. Multiple orange signals indicate amplification of MYC.

Expected Patterns

Expected Pattern 1

Normal Cell:
Two green (2G) and two orange (2O) signals.

Expected Pattern 2

Aberrant Cell (typical results):
Two green (2G), one orange (1O), and orange signal clusters, indicating amplification of MYC (homogenous staining region = HSR).

Expected Pattern 3

Aberrant Cell (typical results): Two green (2G) and multiple copies of orange signals, indicating amplification of MYC (double minutes = dm).

Literature

  • Rummukainen et al (2001) Mod Pathol 14:1030-1035
  • Blancato et al (2004) Br J Cancer 90:1612-1619
  • Singhi et al (2012) Mod Pathol 25:378-387

Downloads

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