XL MYC amp

Amplification Probe

Order Number
D-6008-100-OG
Package Size
100 µl (10 Tests)
Labels
  
Chromosome
8

Description

XL MYC amp

XL MYC amp consists of an orange-labeled probe hybridizing to the MYC gene region at 8q24.21 and a green-labeled probe hybridizing to the centromere of chromosome 8.

Probe maps are created in accordance with the intended purpose of the product. Solid colored bars do not necessarily indicate that the probe fully covers the indicated genomic region. Therefore, caution is advised when interpreting results generated through off-label use. Probe map details based on UCSC Genome Browser GRCh37/hg19. Map components not to scale. Further information is available on request.

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Clinical Details

Amplification of MYC has been described in many types of tumor, including breast, cervical and colon cancers, as well as in squamous cell carcinomas of the head and neck, myeloma, non-Hodgkin lymphoma, gastric adenocarcinomas and ovarian cancer. MYC is the most frequently amplified oncogene and the elevated expression of its gene product correlates with tumor aggression and poor clinical outcome.
The proto-oncogene MYC, located at 8q24.1, encodes a nuclear phosphoprotein transcription factor which has an integral role in a variety of cellular processes, such as cell cycle progression, proliferation, metabolism, adhesion, differentiation, and apoptosis.

Clinical Applications

  • Solid Tumors (Solid Tumors)
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Images

XL MYC amp

XL MYC amp hybridized to breast cancer tissue. Multiple orange signals indicate amplification of MYC.

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Expected Patterns

Expected Pattern 1

Normal Cell:
Two green (2G) and two orange (2O) signals.

Expected Pattern 2

Aberrant Cell (typical results):
Two green (2G), one orange (1O), and orange signal clusters, indicating amplification of MYC (homogenous staining region = HSR).

Expected Pattern 3

Aberrant Cell (typical results): Two green (2G) and multiple copies of orange signals, indicating amplification of MYC (double minutes = dm).

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Literature

  • Rummukainen et al (2001) Mod Pathol 14:1030-1035
  • Blancato et al (2004) Br J Cancer 90:1612-1619
  • Singhi et al (2012) Mod Pathol 25:378-387

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