XL MALT1 BA consists of an orange-labeled probe hybridizing proximal to the MALT1 gene region at 18q21.3 and a green-labeled probe hybridizing distal to the MALT1 gene region at 18q21.3.

Probe maps are created in accordance with the intended purpose of the product. Solid colored bars do not necessarily indicate that the probe fully covers the indicated genomic region. Therefore, caution is advised when interpreting results generated through off-label use. Probe map details based on UCSC Genome Browser GRCh37/hg19. Map components not to scale. Further information is available on request.

The MALT1 gene was identified through its involvement in t(11;18)(q21;q21), seen in 30% of cases of mucosa-associated lymphoid tissue (MALT) lymphoma. The t(11;18)(q21;q21) is restricted to MALT lymphomas and has not been detected in nodal or splenic marginal zone lymphomas, diffuse large B-cell lymphomas, or other non-Hodgkin lymphomas. The second most frequent translocation identified in MALT lymphoma is the t(14;18)(q32;q21) IGH/MALT1. The t(14;18)(q32;q21) IGH/MALT1 is found most often in MALT lymphomas arising at non-gastric sites and is identified in 5-25% of cases arising in the ocular adnexa, lung, salivary gland and skin.
The oncogenic activity of MALT1 is linked to its involvement of the CARMA1-BCL10-MALT1 (CBM) complex in antigen receptor-mediated activation of the transcription factor NF-kB, which controls the expression of numerous anti-apoptotic and proliferation-promoting genes.

Clinical Applications

• Non-Hodgkin Lymphomas (NHL)
• Solid Tumors (Solid Tumors)

XL MALT1 BA hybridized to lymphoid tissue. The normal green-orange fusion signal pattern is observed.

• Streubel et al (2003) Blood 101:2335-2339
• Murga Penas et al (2003) Leukemia 17:2225-2229
• Bacon et al (2007) J Clin Pathol 60:361-372