XL MALT1 BA

Break Apart Probe

Order Number
D-6015-100-OG
Package Size
100 µl
Labels
  
Chromosome
18

Description

XL MALT1 BA

The XL MALT1 BA probe is designed as a break apart probe. Its orange labeled part hybridizes proximal to the MALT1 gene at 18q21, the green labeled probe hybridizes to the distal region of MALT1.

This probe is intended for methanol/acetic-acid fixed cells and tissue sections.

Clinical Details

The MALT1 gene was identified through its involvement in t(11;18)(q21;q21), seen in 30% of cases of mucosa-associated lymphoid tissue (MALT) lymphoma. The t(11;18)(q21;q21) is restricted to MALT lymphomas and has not been detected in nodal or splenic marginal zone lymphomas, diffuse large B-cell lymphomas, or other non-Hodgkin lymphomas. The second most frequent translocation identified in MALT lymphoma is the t(14;18)(q32;q21) IGH/MALT1. The t(14;18)(q32;q21) IGH/MALT1 is found most often in MALT lymphomas arising at non-gastric sites, and is identified in 5-25% of cases arising in the ocular adnexa, lung, salivary gland and skin.

The oncogenic activity of MALT1 is linked to it's involvement of the CARMA1-BCL10-MALT1 (CBM) complex in antigen receptor-mediated activation of the transcription factor NF-kB, which controls the expression of numerous anti-apoptotic and proliferation-promoting genes.

Clinical Applications

  • Non-Hodgkin Lymphomas (NHL)
  • Solid Tumors (Solid Tumors)

Images

XL MALT1 BA

XL MALT1 BA hybridized to lymphoid tissue. The normal green-orange fusion signal pattern is observed.

Expected Patterns

Expected Pattern 1

Normal Cell:
Two green-orange (2GO) fusion signals.

Expected Pattern 2

Aberrant Cell (typical results):
One green (1G), one orange (1O), and one green-orange (1GO) fusion signal, indicating a chromosome break in the MALT1 locus.

Literature

  • Streubel et al (2003) Blood 101: 2335-2339
  • Murga Penas et al (2003) Leukemia 17: 2225-2229
  • Bacon et al (2007) J Clin Pathol 60: 361-372

Downloads

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