The meeting of the German Society of Human Genetics (gfh) was held in Weimar, Germany this week and of course the attendees had the opportunity to visit the joined booth of MetaSystems and MetaSystems Probes. Main topics of the exhibition have been the latest advancements of the Neon case and imaging platform and RapidHyb, the revolutionary fast hybridization times of MetaSystems Probes' FISH probes.
XL 19p/19q del
- Order Number
- Package Size
- 100 µl (10 Tests)
XL 19p/19q del detects deletions in the long arm of chromosome 19. The orange labeled probe hybridizes to the GLTSCR1 and GLTSCR2 locus at 19q13. A green labeled probe hybridizes to a specific locus at 19p13 and functions as a reference probe.
This probe is intended for methanol/acetic-acid fixed cells and tissue sections.
The 2016 ´World Health Organization Classification of Tumors of the Central Nervous System´(WHO 2016) combines, for the first time, histological features and molecular signatures for the definition of many tumor entities. Gliomas are a category of tumors of the brain and spinal cord starting in glia cells. Oligodendrogliomas are a subtype of gliomas accounting for up to 18% of all cases. According to the WHO 2016, the classification of an oligodendroglioma requires information about the isocitrate dehydrogenase mutation status and 1p/19q loss of heterozygosity (LOH). LOH of 19q can be detected in about 80% of oligodendroglial tumors and to a lower extend in mixed gliomas. Co-deletion of 1p/19q is a well-accepted prognostic biomarker in neuro-oncology. Patients suffering from anaplastic oligodendroglioma harboring 1p/19q deletion, generally have a good prognosis. Co-deletion of 1p/19q has also predictive character, the molecular status of 1p/19q is relevant for therapy decisions.
- Solid Tumors (Solid Tumors)
Two green (2G) and two orange (2O) signals.
Aberrant Cell (typical results):
Two green (2G) and one orange (1O) signal resulting from loss of one orange signal.
- Reifenberger et al (1994) Am J Pathol 145:1175-1190
- Louis et al (2016) Acta Neuropathol 131:803-820
- Staedtke et al (2016) Trends Cancer 2:338-349