XL MYC BA consists of an orange-labeled probe hybridizing proximal to the MYC gene region at 8q24.21 and a green-labeled probe hybridizing distal to the MYC gene region at 8q24.21.

Probe maps for selected products have been updated. These updates ensure a consistent presentation of all gaps larger than 10 kb including adjustments to markers, genes, and related elements. This update does not affect the device characteristics or product composition. Please refer to the list to find out which products now include updated probe maps.

Probe map details are based on UCSC Genome Browser GRCh37/hg19, with map components not to scale.

Translocations involving MYC are observed in diffuse large-B-cell lymphoma, follicular lymphoma, mantle cell lymphoma, and other lymphomas. In Burkitt Lymphoma, the MYC gene, located at 8q24, is activated by a translocation next to an immunoglobulin constant gene. Most frequently, MYC is positioned near the immunoglobulin heavy-chain (IGH) constant region on chromosome 14q32. However, in some tumors MYC can also be positioned near the light-chain region on chromosome 2p11 (IGK) or 22q11 (IGL). In addtion, other translocation partners have been identified (e.g. BCL11A, PAX5, ZCCHC7).

The XL MYC probe is designed as a break apart probe with two probes juxtaposed and differentially labeled. The proximal and distal regions are sufficiently large to achieve intense signals also on paraffin-embedded tissue sections. The wide gap between the orange and green part of this probe allows for the detection of the t(2;8) translocation as well as t(8;14) and t(8;22).

Clinical Applications

• Non-Hodgkin Lymphomas (NHL)
• Solid Tumors (Solid Tumors)

XL MYC BA hybridized to lymphocytes. Separate orange and green signals indicate a split in the MYC gene region.

• Hummel et al (2006) N Engl J Med 354:2419-2430
• Einerson et al (2006) Leukemia 20:1790-1799
• Bertrand et al (2007) Leukemia 21:515-523