The meeting of the German Society of Human Genetics (gfh) was held in Weimar, Germany this week and of course the attendees had the opportunity to visit the joined booth of MetaSystems and MetaSystems Probes. Main topics of the exhibition have been the latest advancements of the Neon case and imaging platform and RapidHyb, the revolutionary fast hybridization times of MetaSystems Probes' FISH probes.
XL IRF4 BA
Break Apart Probe
- Order Number
- Package Size
- 100 µl (10 Tests)
The updated (2016) revision of the World Health Organization (WHO) classification of tumors of lymphoid neoplasms considers the large B-cell lymphoma with IRF4 rearrangement as a new provisional entity. Head and neck regions including the Waldeyer ring are particularly affected. Chromosomal translocations involving the IRF4 gene and the immunoglobulin loci IGH, IGL and IGK (IG) result in dysregulation of IRF4 expression, other translocation partners may occur. Since t(6;14)(p25;q32) is cytogenetically cryptic, FISH is a valuable tool in detecting this recurrent aberration. IG/IRF4 positive lymphomas normally lack t(14;18), observed in about 85% of adult patients with follicular lymphoma, and are commonly associated with young age and a good course. IRF4 rearrangements have also been identified in peripheral T-cell lymphomas (PTCL). PTCL are defined as a diverse group of aggressive lymphomas of mature-stage T-cells accounting for about 10% of non-Hodgkin lymphomas. Recent data suggests, that IRF4 translocations detected by FISH have a predictive value for primary cutaneous CD30(+) anaplastic large cell lymphoma.
- Non-Hodgkin Lymphomas (NHL)
Two green-orange colocalization/fusion signals (2GO).
Aberrant Cell (typical results):
One green-orange colocalization/fusion signal (1GO), one separate green (1G) and orange (1O) signal each resulting from a chromosome break in the relevant locus.
- Feldman et al (2009) Leukemia 23:574-580
- Salaverria et al (2011) Blood 7:139-147
- Kiran et al (2013) Leukemia Research 37:396-400