MetaSystems Probes has received IVDR certification for our XCyting FISH probes for prenatal aneusomy testing – the XA aneusomy probes.
Our Complete Set of XA Aneusomy Probes for Prenatal Testing Is IVDR Certified.
XA AneuScore II
Aneusomy Probe
- Order Number
- D-5609-500-TC
- Package Size
- (2x 50 Tests)
- Regulatory Status
- IVDD
IVDR Certification
This probe is IVDR-certified in compliance with the Regulation (EU) 2017/746 on in vitro diagnostic medical devices (IVDR).
MetaSystems Probes has already certified a large part of its portfolio, according to IVDR. For organizational reasons, we currently provide only the IVDD product.
The XA AneuScore II Probe Kit contains different probe mix, provided in separate test vials, for assessing chromosomal aneuploidies for chromosomes 13, 18, 21, X, and Y.
XA 13/18/21 (D-5607-100-TC):
The XA 13/18/21 mix of specific probes allows detecting copy number variations of chromosomes 13, 18, and 21. The green labeled probe hybridizes to a region at 13q14 including the RB1 locus, the blue (aqua) labeled probe hybridizes to a locus at 18q21, and the orange labeled probe hybridizes to a region at 21q22 including the DSCR4 (Down syndrome critical region 4).
XA X/Y (D-5608-100-OG):
The XA X/Y mix of specific probes allows detecting copy number variations for chromosomes X and Y. The probe mix is composed of repetitive sequences which hybridize to the centromeric region of chromosomes X in green and Y in orange.
Probe maps are created in accordance with the intended purpose of the product. Solid colored bars do not necessarily indicate that the probe fully covers the indicated genomic region. Therefore, caution is advised when interpreting results generated through off-label use. Probe map details based on UCSC Genome Browser GRCh37/hg19. Map components not to scale. Further information is available on request.
Numerical aberrations of autosomes 13, 18, 21, and sex chromosomes X and Y account for 95% of birth defects in newborns. FISH applied to uncultured amniocytes provides a method to identify those aberrations considerably faster than conventional chromosome analysis. Nowadays, it is widely accepted to provide preliminary results for the detection of anomalies in less than 12 hours.
Available in two package sizes:
D-5609-100-TC XA AneuScore II, 10 Tests
D-5609-500-TC XA AneuScore II, 50 Tests
XA 13/18/21 and XA X/Y hybridized to uncultured amniocytes. One interphase and one metaphase are shown for each probe mix.
For signal patterns please refer to: XA 13/18/21 (D-5607-100-TC) and XA X/Y (D-5608-100-OG).
- Bryndorf et al (1996) Am J Hum Genet 59:918-926
- Tepperberg et al (2001) Prenat Diagn 21:293-301
- Stumm et al (2006) Cytogenet Genome Res 114:296-301
Package Insert (EN)Package Insert (IT)Probes Catalog
Certificate of Analysis (CoA)
or go to CoA DatabaseIVDR Certification
MetaSystems Probes has received IVDR certification for our initial 26 fluorescence in situ hybridization (FISH) probes from the notified body, BSI. Achieving this milestone was not without its challenges, and we are delighted to have accomplished IVDR certification for this probe set at an early stage.
Over 50 XCyting FISH Probes are IVDR-Certified!
The IVDR is effective and our probes stay the same! A large segment of our portfolio is already IVDR-certified. Our priority is to give you a smooth transition into the IVDR era.
