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XL t(8;14) MYC/IGH DF 8cen

Translocation/Dual Fusion Probe

Order Number
D-5125-100-TC
Package Size
100 µl (10 Tests)
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Chromosomes
814
Regulatory Status
IVDD

IVDR Certification

MetaSystems Probes has already certified a large part of its portfolio, according to IVDR. For organizational reasons, we currently provide only the IVDD product.

Discover all IVDR-certified products

Product Description

XL t(8;14) MYC/IGH DF 8cen

XL t(8;14) MYC/IGH DF 8cen consists of an aqua-labeled probe hybridizing to the centromere of chromosome 8, an orange-labeled probe hybridizing to the MYC gene region at 8q24.21 and a green-labeled probe hybridizing to the IGH gene region at 14q32.3.

Probe maps are created in accordance with the intended purpose of the product. Solid colored bars do not necessarily indicate that the probe fully covers the indicated genomic region. Therefore, caution is advised when interpreting results generated through off-label use. Probe map details based on UCSC Genome Browser GRCh37/hg19. Map components not to scale. Further information is available on request.

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Clinical Details

Clinical Applications

  • Non-Hodgkin Lymphomas (NHL)
  • Acute Lymphoblastic Leukemia (ALL)
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Images

XL t(8;14) MYC/IGH DF 8cen

XL t(8;14) MYC/IGH DF 8cen hybridized to lymphocytes. One normal interphase and metaphase are shown.

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Expected Patterns

Expected Pattern 1

Normal Cell:
Two blue (2B), two green (2G) and two orange (2O) signals.

Expected Pattern 2

Aberrant Cell (typical results):
Two blue (2B), one green (1G), one orange (1O), and two green-orange colocalization/fusion signals (2GO) resulting from a reciprocal translocation between the respective loci.

Expected Pattern 3

Aberrant Cell (typical results):
Three blue (3B), two green (2G), and three orange (3O) signals resulting from a gain of the orange/blue labeled chromosome.

Expected Pattern 4

Aberrant Cell (typical results):
Two blue (2B), two green (2G), and three orange (3O) signals resulting from a translocation between the orange labeled and an unknown chromosome.

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Literature

  • Siebert et al (1998) Blood 91:984-990
  • Boerma et al (2009) Leukemia 23:225-234
  • Nguyen et al (2017) Genes 8:1-23

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News


IVDR Certification

MetaSystems Probes has received IVDR certification for our initial 26 fluorescence in situ hybridization (FISH) probes from the notified body, BSI. Achieving this milestone was not without its challenges, and we are delighted to have accomplished IVDR certification for this probe set at an early stage.

IVDR Certification