The yearly MetaSystems Distributor Meeting (DM), brought into life in 2002 as a platform to gather all international partners of MetaSystems and other members of the global MetaSystems family, just ended last week. The DM is being organized in turns by MetaSystems Headquarters, MetaSystems USA (MGI), and MetaSystems Asia. Since MGI is celebrating its 25th anniversary in 2018 they decided to choose a special location: Nassau, The Bahamas!
Break Apart Probe
- Order Number
- Package Size
- 100 µl
Acute Lymphoblastic Leukemia (ALL) is the most common type of leukemia in children, representing almost 25 % of pediatric cancer. The majority of patients with ALL demonstrate an abnormal karyotype, either in chromosome number or as structural changes such as translocations, inversions, or deletions.
E2A (also termed TCF3) is the target of three known recurrent genomic rearrangements in ALL. The t(1;19)(q23;p13.3) occurs in approximately 5 % of cases and is the second most common translocation in ALL. The t(17;19)(q22;p13) occurs in about 1 % of ALLs and fuses E2A to the chromosome 17 gene HLF. A recently described cryptic inversion of chromosome 19 fuses E2A to the 19q13.4 gene FB1.
- Acute Lymphoblastic Leukemia (ALL)
Two green-orange fusion signals (2GO).
Aberrant Cell (typical results):
One green-orange fusion signal (1GO), one separate green (1G) and one orange (1O) signal each resulting from a chromosome break in the relevant locus.
- Boomer et al (2001) Leukemia 15:95-102
- Van der Burg et al (2004) Leukemia 18:895-908
- Kager et al (2007) Haematologica 92:1561-1564