XL PML/RARA

Translocation/Dual Fusion Probe

Order Number
D-5023-100-OG
Package Size
100 µl
Labels
  
Chromosomes
1517

Description

XL PML/RARA

This product has been replaced by XL t(15;17) DF. Order Number D-5086-100-OG

Clinical Details

Several recurrent balanced translocations and inversions, and their variants, are recognized in the WHO category acute myeloid leukemia (AML) with recurrent genetic abnormalities. Furthermore, several cytogenetic abnormalities are considered sufficient to establish the WHO diagnosis of AML with myelodysplasia-related features when 20% or more blood or marrow blasts are present.

AML M3 and AML M3v are characterized by a reciprocal translocation between the long arm of chromosome 15 and the long arm of chromosome 17. This translocation leads to a rearrangement of the PML-gene situated on chromosomal band 15q24 and the RARA-gene situated on band 17q21. The PML-RARA-rearrangement has gained major clinical importance as combining ´all transretinoic acid´ and conventional anthracy-cline-cytarabin based chemotherapy has improved the prognosis in this subgroup of AML dramatically.

Clinical Applications

  • Acute Myelogenous Leukemia (AML)

Images

XL PML/RARA

XL PML/RARA was hybridized to lymphocytes. Two normal interphase cells are shown.

Expected Patterns

Expected Pattern 1

Normal Cell:
Two green (2G) and two orange (2O) signals.

Expected Pattern 2

Aberrant Cell (typical results):
One green (1G), one orange (1O), and two green-orange signals (2GO).

Literature

  • Lafage-Pochitaloff et al (1995) Blood 85:1169-1174
  • Grimwade et al (2000) Blood 96:1297-1308
  • Schoch et al (2002) Hematol-J 3:259-263

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