XL AML1

Break Apart Probe

Order Number
D-5027-100-OG
Package Size
100 µl
Labels
  
Chromosome
21

Description

XL AML1

This product has been replaced by XL RUNX1. Order Number D-5096-100-OG

Clinical Details

Several recurrent balanced translocations and inversions, and their variants, are
recognized in the WHO category acute myeloid leukemia (AML) with recurrent genetic abnormalities. Furthermore, several cytogenetic abnormalities are considered sufficient to establish the WHO diagnosis of AML with myelodysplasia-related features when 20% or more blood or marrow blasts are present.

The AML1 (RUNX1) gene on human chromosome 21q22.12 belongs to the 'runt domain' gene family of transcription factors. It is a key regulator of hematopoiesis and a frequent target of leukemia associated chromosomal translocations. RUNX1 can either activate or repress transcription of target genes, depending on the protein isoform, and is able to interact with other transcriptional regulators.

Clinical Applications

  • Acute Lymphoblastic Leukemia (ALL)
  • Acute Myelogenous Leukemia (AML)

Images

XL AML1

XL AML1 hybridized to lymphocytes. One normal interphase and metaphase are shown.

Expected Patterns

Expected Pattern 1

Normal Cell:
Two green-orange (2GO) fusion signals representing the two normal AML1 loci.

Expected Pattern 2

Aberrant Cell (typical results):
One green (1G), one orange (1O), and one green-orange (1GO) fusion signals, indicating a chromosome break in the AML1 locus.

Literature

  • Levanon et al (2001) Gene 262:23-33
  • Zhang et al (2002) Proc Natl Acad Sci USA 99:3070-3075

Downloads

Order Now or Request Assistance

Contact Us »

Contact MetaSystems directly or find your local MetaSystems partner.