XL PDGFRB

Break Apart Probe

Order Number
D-5031-100-OG
Package Size
100 µl
Labels
  
Chromosome
5

Description

XL PDGFRB

This product has been replaced by XL 5q32 PDGFRB BA. Order Number D-5104-100-OG

Clinical Details

In 2008 the World Health Organization (WHO) classification of tumors of hematopoietic and lymphoid tissues introduced a new category for myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, or FGFR1. Many of these cases present as a myeloproliferative neoplasm, usually with eosinophilia.

Myeloid neoplasms (MPNs) with rearrangement of PDGFRB are phenotypically and genotypically diverse. The fusion genes involving PDGFRB described to date have been associated with cytogenetically detectable translocations. MPNs associated with rearrangement of PDGFRB are responsive to Imatinib.

Clinical Applications

  • Chronic Myelogenous Leukemia and Myeloproliferative Neoplasms (CML/MPN)

Images

XL PDGFRB

XL PDGFRB hybridized to normal lymphocytes. Three interphases are displayed showing two fusion signals each.

Expected Patterns

Expected Pattern 1

Normal Cell:
Two green-orange fusion signals (2GO) representing the two normal PDGFRB loci.

Expected Pattern 2

Aberrant Cell (typical results):
One green-orange fusion signal (1GO) and one green (1G), one orange (1O) indicating a chromosome break in the PDGFRB locus.

Literature

  • Wlodarska et al (1997) Blood 89:1716-1722
  • Apperley et al (2002) N Engl J Med 347:481-487
  • Wilkinson et al (2003) Blood 102:4187-4190

Downloads

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