The yearly MetaSystems Distributor Meeting (DM), brought into life in 2002 as a platform to gather all international partners of MetaSystems and other members of the global MetaSystems family, just ended last week. The DM is being organized in turns by MetaSystems Headquarters, MetaSystems USA (MGI), and MetaSystems Asia. Since MGI is celebrating its 25th anniversary in 2018 they decided to choose a special location: Nassau, The Bahamas!
XL IGH plus
Break Apart Probe
- Order Number
- Package Size
- 100 µl
Chromosomal translocations affecting the IGH locus are recurrent in many types of lymphomas. The malignant transformation works via the juxtaposition of oncogenes next to regulatory sequences of the immunoglobulin locus.
Due to the telomeric position of the IgH locus, 14q32.3 translocations may be easily missed by conventional cytogenetics. A break apart IGH probe covering the central IGHV region and located proximally from IGHJ close to the JAG2 gene, allows to identify most IGH rearrangements independent of breakpoint variations.
- Multiple Myeloma and Plasma Cell Neoplasms (MM)
- Non-Hodgkin Lymphomas (NHL)
- Acute Lymphoblastic Leukemia (ALL)
Two green-orange (2GO) fusion signals representing the two normal IGH loci.
Aberrant Cell (typical results):
One green (1G), one orange (1O), and one green-orange (1GO) fusion signal, indicating a chromosome break in the IGH locus.
- Martin-Subero et al (2006) Cancer Res 66:10332-10338
- Wlodarska et al (2007) J Mol Diagn 9:47-54
- Dyer et al (2010) Blood 115:1490-1499