XL t(11;14)

Translocation/Dual Fusion Probe

Order Number
D-5062-100-OG
Package Size
100 µl
Labels
  
Chromosomes
1114

Description

XL t(11;14)

This product has been replaced by XL t(11;14) MYEOV/IGH DF. Order Number D-5111-100-OG

Clinical Details

Genetic aberrations present in multiple myeloma cells play a significant role in the risk stratification and therapeutic approach in multiple myeloma patients. Chromosomal translocations affecting the IGH locus are recurrent in many types of leukemias and lymphomas.The malignant transformation works via the juxtaposition of oncogenes next to regulatory sequences of the immunoglobulin locus.

The t(11;14)(q13;q32) results in up-regulation of cyclin D1 and is the most common translocation detected in multiple myeloma. This translocation represents a unique subset of patients with a relatively favorable outcome. The t(11;14) is also the genetic hallmark of mantle cell lymphoma.

Clinical Applications

  • Multiple Myeloma and Plasma Cell Neoplasms (MM)
  • Non-Hodgkin Lymphomas (NHL)
  • Chronic Lymphocytic Leukemia (CLL)

Images

XL t(11;14)

XL t(11;14) hybridized to lymphocytes. One normal metaphase and two normal interphases are shown.

Expected Patterns

Expected Pattern 1

Normal Cell:
Two green (2G) and two orange signals (2O).

Expected Pattern 2

Aberrant Cell (typical results):
One green (1G), one orange (1O), and two green-orange fusion signals (2GO).

Literature

  • Jansen et al (2000) Blood 95:2691-2698
  • Fonseca et al (2002) Blood 99:3735-3741
  • Sander et al (2008) Haematologica 93:680-687

Downloads

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