The yearly MetaSystems Distributor Meeting (DM), brought into life in 2002 as a platform to gather all international partners of MetaSystems and other members of the global MetaSystems family, just ended last week. The DM is being organized in turns by MetaSystems Headquarters, MetaSystems USA (MGI), and MetaSystems Asia. Since MGI is celebrating its 25th anniversary in 2018 they decided to choose a special location: Nassau, The Bahamas!
Translocation/Dual Fusion Probe
- Order Number
- Package Size
- 100 µl
Genetic aberrations present in multiple myeloma cells play a significant role in the risk stratification and therapeutic approach in multiple myeloma patients. Chromosomal translocations affecting the IGH locus are recurrent in many types of leukemias and lymphomas.The malignant transformation works via the juxtaposition of oncogenes next to regulatory sequences of the immunoglobulin locus.
The t(4;14)(p16;q32) is a primary event in multiple myeloma (MM) and deregulates the expression of the fibroblast growth factor receptor 3 (FGFR3) and MMSET. Multivariate analysis has identified t(4;14) as the only adverse prognostic factor for both progression-free survival and overall survival.
- Multiple Myeloma and Plasma Cell Neoplasms (MM)
Two green (2G) and two orange signals (2O).
Aberrant Cell (typical results):
One green (1G), one orange (1O), and two green-orange fusion signals (2GO).
- Chesi et al (1998) Blood 92:3025-3034
- Chang et al (2004) Br J Haematol 125:64-68
- Saez et al (2007) Onco Reports 18:1099-1106