XL t(4;14)

Translocation/Dual Fusion Probe

Order Number
D-5064-100-OG
Package Size
100 µl
Labels
  
Chromosomes
414

Description

XL t(4;14)

This product has been replaced by XL t(4;14) IGH/FGFR3 DF. Order Number D-5108-100-OG.

Clinical Details

Genetic aberrations present in multiple myeloma cells play a significant role in the risk stratification and therapeutic approach in multiple myeloma patients. Chromosomal translocations affecting the IGH locus are recurrent in many types of leukemias and lymphomas.The malignant transformation works via the juxtaposition of oncogenes next to regulatory sequences of the immunoglobulin locus.

The t(4;14)(p16;q32) is a primary event in multiple myeloma (MM) and deregulates the expression of the fibroblast growth factor receptor 3 (FGFR3) and MMSET. Multivariate analysis has identified t(4;14) as the only adverse prognostic factor for both progression-free survival and overall survival.

Clinical Applications

  • Multiple Myeloma and Plasma Cell Neoplasms (MM)

Images

XL t(4;14)

XL t(4;14) hybridized to lymphocytes. One normal metaphase and two normal interphases are shown.

Expected Patterns

Expected Pattern 1

Normal Cell:
Two green (2G) and two orange signals (2O).

Expected Pattern 2

Aberrant Cell (typical results):
One green (1G), one orange (1O), and two green-orange fusion signals (2GO).

Literature

  • Chesi et al (1998) Blood 92:3025-3034
  • Chang et al (2004) Br J Haematol 125:64-68
  • Saez et al (2007) Onco Reports 18:1099-1106

Downloads

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