XL ETV6

Break Apart Probe

Order Number: D-5073-100-OG

Package Size: 100 µl (10 Tests)

Labels: orange green

Chromosome: 1212

Regulatory Status: IVDD

XL ETV6

Break Apart Probe

Order Number: D-5073-100-OG

Package Size: 100 µl (10 Tests)

Labels: orange green

Chromosome: 1212

Regulatory Status: IVDD

IVDR Certification

This probe is IVDR-certified in compliance with the Regulation (EU) 2017/746 on in vitro diagnostic medical devices (IVDR).

MetaSystems Probes has already certified a wide range of FISH probes, according to IVDR.

This product remains IVDD-certified until further notice.

Please use the switch to change to the IVDR product.

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Product Description

XL ETV6 consists of an orange-labeled probe hybridizing proximal to the ETV6 gene region at 12p13.2 and a green-labeled probe hybridizing distal to the ETV6 gene region at 12p13.2.

Probe maps for selected products have been updated. These updates ensure a consistent presentation of all gaps larger than 10 kb including adjustments to markers, genes, and related elements. This update does not affect the device characteristics or product composition. Please refer to the list to find out which products now include updated probe maps.

Probe map details are based on UCSC Genome Browser GRCh37/hg19, with map components not to scale.

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Clinical Details

Clinical Applications

Acute Lymphoblastic Leukemia (ALL)
Acute Myelogenous Leukemia (AML)
Chronic Myelogenous Leukemia and Myeloproliferative Neoplasms (CML/MPN)

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Images

XL ETV6 hybridized to lymphocytes. One normal interphase and metaphase are shown.

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Expected Patterns

Normal Cell:
Two green-orange colocalization/fusion signals (2GO).

Aberrant Cell (typical results):
One green-orange colocalization/fusion signal (1GO),one separate green (1G) and orange (1O) signal each resulting from a chromosome break in the respective locus.

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