The yearly MetaSystems Distributor Meeting (DM), brought into life in 2002 as a platform to gather all international partners of MetaSystems and other members of the global MetaSystems family, just ended last week. The DM is being organized in turns by MetaSystems Headquarters, MetaSystems USA (MGI), and MetaSystems Asia. Since MGI is celebrating its 25th anniversary in 2018 they decided to choose a special location: Nassau, The Bahamas!
XL t(14;18) IGH/BCL2
Translocation/Dual Fusion Probe
- Order Number
- Package Size
- 100 µl
Follicular lymphomas (FL) and diffuse large cell lymphoma (DLBCL) represent the most common entities of non-Hodgkin's lymphoma (NHL) worldwide with up to 29 % and 37 % of B-cell lymphomas.
The translocation t(14;18) juxtaposes the IGH enhancer region with the BCL-2 oncogen at 18q21 and is present in 70 % to 95 % of follicular lymphomas. By this rearrangement BCL-2 gene expression is deregulated, leading to overproduction of the antiapoptotic protein BCL-2. The same aberration is present in 20 - 30 % of diffuse large cell lymphomas.
- Non-Hodgkin Lymphomas (NHL)
Two green (2G) and two orange signals (2O).
Aberrant Cell (typical results):
One green (1G), one orange (1O), and two green-orange fusion signals (2GO).
- Einerson et al (2005) Am J Clin Pathol 124:421-429
- Weinberg et al (2007) J Mol Diagn 9:530-537
- Gu et al (2008) Arch Pathol Lab Med 132:1355-1361