XL IGH/MYC/8cen

Translocation/Dual Fusion and Amplification Probe

Order Number
D-5094-100-TC
Package Size
100 µl
Labels
   
Chromosomes
814

Description

XL IGH/MYC/8cen

This product has been replaced by XL t(8;14) MYC/IGH DF 8cen. Order Number D-5125-100-TC

Clinical Details

Chromosomal translocations affecting the IGH locus are recurrent in many types of lymphomas. The malignant transformation works via the juxtaposition of oncogenes next to regulatory sequences of the immunoglobulin locus.

The t(8;14)(q24;q32) MYC/IGH is the hallmark translocation of human Burkitt lymphoma where it accounts for about 85% of cases. The same translocation can be present in almost 5% of ALL patients and in diffuse large B-cell lymphomas. Although this aberration is often described to indicate a good prognosis, it can be an indicator of bad prognosis if associated with other factors, such as second aberrations like t(14;18) or BCL6 rearrangements.

Clinical Applications

  • Non-Hodgkin Lymphomas (NHL)
  • Acute Lymphoblastic Leukemia (ALL)

Images

XL IGH/MYC/8cen

XL IGH/MYC/8cen hybridized to a lymphocyte cell. Two fusion signals indicate a t(8;14). One green and orange signal represent the normal chromosomes 8 and 14. Two blue signals show the presence of two copies of chromosome 8.

Expected Patterns

Expected Pattern 1

Normal Cell:
Two blue (2B), two green (2G), and two orange (2O) signals.

Expected Pattern 2

Aberrant Cell (typical results):
Two blue (2B), one green (1G), one orange (1O), and two green-orange (2GO) fusion signals.

Expected Pattern 3

Aberrant Cell (typical results):
Three blue (3B), two green (2G), and three orange (3O) signals indicating a trisomy 8.

Literature

  • Siebert et al (1998) Blood 91:984-990
  • Hummel et al (2006) N Engl J Med 354:2419-30
  • Boerma et al (2009) Leukemia 23:225-234

Downloads

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