The XL Acro-p probe contains sequences which specifically hybridize to the short (p) arm of all human acrocentric chromosomes. The XL Acro-p FISH probe may replace conventional silver staining used to stain the NOR regions.

Probe maps are created in accordance with the intended purpose of the product. Solid colored bars do not necessarily indicate that the probe fully covers the indicated genomic region. Therefore, caution is advised when interpreting results generated through off-label use. Probe map details based on UCSC Genome Browser GRCh37/hg19. Map components not to scale. Further information is available on request.

Variations in length of stalks and satellites of human acrocentric chromosomes are considered as normal variable chromosome features. However, cryptic translocations can result in unbalanced karyotypes but might be misinterpreted as common acrocentric short arm polymorphisms.

XL Acro-p was hybridized to normal lymphocytes. A metaphase with orange signals at band p12 of all acrocentric chromosomes (13, 14, 15, 21 and 22) is shown.

• Benzacken et al (2001) Prenat Diagn 21:96-98

• Utility and performance of bacterial artificial chromosomes-on-beads assays in chromosome analysis of clinical prenatal samples, products of conception and blood samples.
• A child with multiple congenital anomalies due to partial trisomy 7q22.1 → qter resulting from a maternally inherited balanced translocation: a case report and review of literature.
• Distinct roles of ATM and ATR in the regulation of ARP8 phosphorylation to prevent chromosome translocations.
• Heterogeneous MYCN amplification in neuroblastoma: a SIOP Europe Neuroblastoma Study.
• Immense random colocalization, revealed by automated high content image cytometry, seriously questions FISH as gold standard for detecting EML4-ALK fusion.
• Fluorescence in situ hybridisation assays designed for del(7q) detection uncover more complex rearrangements in myeloid leukaemia cell lines
• Detection of t(7;12)(q36;p13) in paediatric leukaemia using dual colour fluorescence in situ hybridisation.
• A rare case of t(11;22) in a mantle cell lymphoma like B-cell neoplasiaresulting in a fusion of IGL and CCND1: case report.
• Genomic DNA-chip hybridization in t(11;14)-positive mantle cell lymphomas shows a high frequency of aberrations and allows a refined characterization of consensus regions.