Fluorescence in situ hybridization has become an essential detection assay in today´s routine diagnostics. However, long hybridization times of many hours to overnight are still a restrictive factor. We have refined the production process of our FISH probes to reduce background and artefacts and to improve the signal to noise ratio, particularly in short-time hybridization. Since mid-2015, one hour hybridization on lymphocytes is an integral part of quality control for all XCyting locus-specific probes at our manufacturing facility.
- Order Number
- Package Size
- 50 µl
Variations in length of stalks and satellites of human acrocentric chromosomes are considered as normal variable chromosome features. However, cryptic translocations can result in unbalanced karyotypes but might be misinterpreted as common acrocentric short arm polymorphisms.
- Benzacken et al (2001) Prenat Diagn 21:96-98