XL Acro-p

Order Number
D-5440-050-OR
Package Size
50 µl (5 Tests)
Labels
 
Chromosomes
1314152122

Description

XL Acro-p

The XL Acro-p probe contains sequences which specifically hybridize to the short (p) arm of all human acrocentric chromosomes. The XL Acro-p FISH probe may replace conventional silver staining used to stain the NOR regions.

Probe maps are created in accordance with the intended purpose of the product. Solid colored bars do not necessarily indicate that the probe fully covers the indicated genomic region. Therefore, caution is advised when interpreting results generated through off-label use. Probe map details based on UCSC Genome Browser GRCh37/hg19. Map components not to scale. Further information is available on request.

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Clinical Details

Variations in length of stalks and satellites of human acrocentric chromosomes are considered as normal variable chromosome features. However, cryptic translocations can result in unbalanced karyotypes but might be misinterpreted as common acrocentric short arm polymorphisms.

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Images

XL Acro-p

XL Acro-p was hybridized to normal lymphocytes. A metaphase with orange signals at band p12 of all acrocentric chromosomes (13, 14, 15, 21 and 22) is shown.

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Literature

  • Benzacken et al (2001) Prenat Diagn 21:96-98

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