XL 21q22 / XCP 21

Order Number
D-5441-050-OG
Package Size
50 µl
Labels
  
Chromosome
21

Description

XL 21q22 / XCP 21

The XL 21q22/XCP 21 is a combination of a whole chromosome paint 21 in green with an orange labeled locus-specific probe for 21q22. This probe allows analysis of copy numbers and structural aberrations of chromosome 21 on metaphase chromosomes.

Clinical Details

This probe is not intended for use to analyze trisomy 21 in prenatal diagnosis.

XL 21q22/XCP 21 hybridized to normal human metaphase spreads will result in green signals along the entire length of chromosome 21 combined with orange signals at 21q22 (Down Syndrome Critical Region 4). A translocation with involvement of chromosome 21 will result in a split of a green signal. In this case the green signal will be partially visible on the der(21) and the respective partner chromosome of the translocation. Depending on the localization of the breakpoint on the der(21), the signal of the locus-specific probe remains on the der(21) or will be observed on the translocation partner.

Images

XL 21q22 / XCP 21

XL 21q22/XCP21 was hybridized to normal lymphocytes. A metaphase with chromosomes 21 painted in green and orange signals at 21q22 is shown.

Downloads

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