XL MALT1 BA

Break Apart Probe

Order Number
D-6015-100-OG
Package Size
100 µl (10 Tests)
Labels
  
Chromosome
18
Regulatory Status
IVDD

IVDR Certification

MetaSystems Probes has already certified a large part of its portfolio, according to IVDR. For organizational reasons, we currently provide only the IVDD product.

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Product Description

XL MALT1 BA

XL MALT1 BA consists of an orange-labeled probe hybridizing proximal to the MALT1 gene region at 18q21.3 and a green-labeled probe hybridizing distal to the MALT1 gene region at 18q21.3.

Probe maps are created in accordance with the intended purpose of the product. Solid colored bars do not necessarily indicate that the probe fully covers the indicated genomic region. Therefore, caution is advised when interpreting results generated through off-label use. Probe map details based on UCSC Genome Browser GRCh37/hg19. Map components not to scale. Further information is available on request.

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Clinical Details

The MALT1 gene was identified through its involvement in t(11;18)(q21;q21), seen in 30% of cases of mucosa-associated lymphoid tissue (MALT) lymphoma. The t(11;18)(q21;q21) is restricted to MALT lymphomas and has not been detected in nodal or splenic marginal zone lymphomas, diffuse large B-cell lymphomas, or other non-Hodgkin lymphomas. The second most frequent translocation identified in MALT lymphoma is the t(14;18)(q32;q21) IGH/MALT1. The t(14;18)(q32;q21) IGH/MALT1 is found most often in MALT lymphomas arising at non-gastric sites and is identified in 5-25% of cases arising in the ocular adnexa, lung, salivary gland and skin.
The oncogenic activity of MALT1 is linked to its involvement of the CARMA1-BCL10-MALT1 (CBM) complex in antigen receptor-mediated activation of the transcription factor NF-kB, which controls the expression of numerous anti-apoptotic and proliferation-promoting genes.

Clinical Applications

  • Non-Hodgkin Lymphomas (NHL)
  • Solid Tumors (Solid Tumors)
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Images

XL MALT1 BA

XL MALT1 BA hybridized to lymphoid tissue. The normal green-orange fusion signal pattern is observed.

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Expected Patterns

Expected Pattern 1

Normal Cell:
Two green-orange (2GO) fusion signals representing the two normal MALT loci.

Expected Pattern 2

Aberrant Cell (typical results):
One green (1G), one orange (1O), and one green-orange (1GO) fusion signal, indicating a chromosome break in the MALT locus.

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Literature

  • Streubel et al (2003) Blood 101:2335-2339
  • Murga Penas et al (2003) Leukemia 17:2225-2229
  • Bacon et al (2007) J Clin Pathol 60:361-372

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News

IVDR Certification

MetaSystems Probes has received IVDR certification for our initial 26 fluorescence in situ hybridization (FISH) probes from the notified body, BSI. Achieving this milestone was not without its challenges, and we are delighted to have accomplished IVDR certification for this probe set at an early stage.

IVDR Certification

New Probes Catalog is Online!

 

MetaSystems Probes is pleased to announce the new catalog including new and innovative products and supporting information. A PDF version of the new catalog is available for download here.

New Probes Catalog is Online!