This product has been replaced by XL t(14;20) IGH/MAFB DF. Order Number D-5105-100-OG
Chromosomal translocations affecting the IGH locus are recurrent in many types of lymphomas. The malignant transformation works via the juxtaposition of oncogenes next to regulatory sequences of the immunoglobulin locus.
Aberrant expression of MAFB is reported to be involved in the oncogenic transformation of myeloma cells that harbor the t(14;20). It can be found in about 2 % of multiple myeloma and less frequent in monoclonal gammopathy of undetermined significance (MGUS) patients. Cases characterized by this translocation can be stable for years before progression occurs.
XL IGH/MAFB hybridized to lymphocytes. One normal interphase and metaphase are shown.
Normal Cell:
Two green (2G) and two orange signals (2O).
Aberrant Cell (typical results):
One green (1G), one orange (1O), and two green-orange fusion signals (2GO).
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The yearly MetaSystems Distributor Meeting (DM), brought into life in 2002 as a platform to gather all international partners of MetaSystems and other members of the global MetaSystems family, just ended last week. The DM is being organized in turns by MetaSystems Headquarters, MetaSystems USA (MGI), and MetaSystems Asia. Since MGI is celebrating its 25th anniversary in 2018 they decided to choose a special location: Nassau, The Bahamas!
The first MetaSystems User Day took place in Altlussheim, Germany in the last week of September 2018. Approximately 25 guests took the opportunity to learn about the benefits of Neon, RapidScore, and the latest MetaSystems FISH probes.
MetaSystems attended the 2018 International Congress of Genetics being held in Foz do Iguacu, Brazil. The conference is known as one of the most important gatherings in the field of genetics in Latin America. Accordingly, the MetaSystems booth traffic was very busy. People from many Latin American countries took the opportunity to learn more about the latest MetaSystems products including Neon, Metafer, and the latest probes.
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