XL IGH/MAFB

Translocation/Dual Fusion Probe

Order Number
D-5051-100-OG
Package Size
100 µl
Labels
  
Chromosomes
1420

Description

XL IGH/MAFB

This product has been replaced by XL t(14;20) IGH/MAFB DF. Order Number D-5105-100-OG

Clinical Details

Chromosomal translocations affecting the IGH locus are recurrent in many types of lymphomas. The malignant transformation works via the juxtaposition of oncogenes next to regulatory sequences of the immunoglobulin locus.

Aberrant expression of MAFB is reported to be involved in the oncogenic transformation of myeloma cells that harbor the t(14;20). It can be found in about 2 % of multiple myeloma and less frequent in monoclonal gammopathy of undetermined significance (MGUS) patients. Cases characterized by this translocation can be stable for years before progression occurs.

Clinical Applications

  • Multiple Myeloma and Plasma Cell Neoplasms (MM)

Images

XL IGH/MAFB

XL IGH/MAFB hybridized to lymphocytes. One normal interphase and metaphase are shown.

Expected Patterns

Expected Pattern 1

Normal Cell:
Two green (2G) and two orange signals (2O).

Expected Pattern 2

Aberrant Cell (typical results):
One green (1G), one orange (1O), and two green-orange fusion signals (2GO).

Literature

  • Boersma-Vreugdenhil et al (2004) Brit J Haem 126:355-363
  • Zhan et al (2006) Blood 108:2020-2028
  • Ross et al (2010) Haematologica 95:1221-1225

Downloads

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