The yearly MetaSystems Distributor Meeting (DM), brought into life in 2002 as a platform to gather all international partners of MetaSystems and other members of the global MetaSystems family, just ended last week. The DM is being organized in turns by MetaSystems Headquarters, MetaSystems USA (MGI), and MetaSystems Asia. Since MGI is celebrating its 25th anniversary in 2018 they decided to choose a special location: Nassau, The Bahamas!
Translocation/Dual Fusion Probe
- Order Number
- Package Size
- 100 µl
Chromosomal translocations affecting the IGH locus are recurrent in many types of lymphomas. The malignant transformation works via the juxtaposition of oncogenes next to regulatory sequences of the immunoglobulin locus.
Aberrant expression of MAFB is reported to be involved in the oncogenic transformation of myeloma cells that harbor the t(14;20). It can be found in about 2 % of multiple myeloma and less frequent in monoclonal gammopathy of undetermined significance (MGUS) patients. Cases characterized by this translocation can be stable for years before progression occurs.
- Multiple Myeloma and Plasma Cell Neoplasms (MM)
Two green (2G) and two orange signals (2O).
Aberrant Cell (typical results):
One green (1G), one orange (1O), and two green-orange fusion signals (2GO).
- Boersma-Vreugdenhil et al (2004) Brit J Haem 126:355-363
- Zhan et al (2006) Blood 108:2020-2028
- Ross et al (2010) Haematologica 95:1221-1225