XL t(6;14)

Translocation/Dual Fusion Probe

Order Number
D-5065-100-OG
Package Size
100 µl
Labels
  
Chromosomes
614

Description

XL t(6;14)

This product has been replaced by XL t(6;14) CCND3/IGH DF. Order Number D-5109-100-OG

Clinical Details

Genetic aberrations present in multiple myeloma cells play a significant role in the risk stratification and therapeutic approach in multiple myeloma patients. Chromosomal translocations affecting the IGH locus are recurrent in many types of leukemias and lymphomas.The malignant transformation works via the juxtaposition of oncogenes next to regulatory sequences of the immunoglobulin locus.

The chromosomal translocation t(6;14)(p21;q32.3) has been reported as a rare but recurrent event not only in myeloma and plasma cell leukemia but also in diffuse large B-cell non-Hodgkin's lymphomas.

Clinical Applications

  • Multiple Myeloma and Plasma Cell Neoplasms (MM)

Images

XL t(6;14)

XL t(6;14) hybridized to lymphocytes. One normal metaphase is shown.

Expected Patterns

Expected Pattern 1

Normal Cell:
Two green (2G) and two orange signals (2O).

Expected Pattern 2

Aberrant Cell (typical results):
One green (1G), one orange (1O), and two green-orange fusion signals (2GO).

Literature

  • Shaugnessy et al (2001) Blood 98:217-223
  • Sonoki et al (2001) Blood 98:2837-2844
  • Wlodarska et al (2008) Blood 111:5683-5690

Downloads

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