The yearly MetaSystems Distributor Meeting (DM), brought into life in 2002 as a platform to gather all international partners of MetaSystems and other members of the global MetaSystems family, just ended last week. The DM is being organized in turns by MetaSystems Headquarters, MetaSystems USA (MGI), and MetaSystems Asia. Since MGI is celebrating its 25th anniversary in 2018 they decided to choose a special location: Nassau, The Bahamas!
Translocation/Dual Fusion Probe
- Order Number
- Package Size
- 100 µl
A number of recurrent chromosomal abnormalities have been shown to have prognostic significance in acute lymphoblastic leukemia, especially in B-precursor ALL. Some chromosomal abnormalities, such as high hyperdiploidy and the ETV6-RUNX1 fusion, are associated with more favorable outcomes, while others, including the t(9;22), rearrangements of the KMT2A gene (chromosome 11q23), and intrachromosomal amplification of the AML1 gene (iAMP21), are associated with a worse prognosis.
The most common translocation is the t(12;21)(p13;q22), which is recognized in up to 25 % of B-precursor ALL. This translocation fuses ETV6 with the RUNX1 gene. The resulting fusion transcript is a transcription factor and functions as a corepressor at RUNX1 target genes. The ETV6/RUNX1 translocation generally implies a good prognosis.
- Acute Lymphoblastic Leukemia (ALL)
Normal Cell: Two green (2G) and two orange signals (2O).
Aberrant Cell (typical results):
One green (1G), one orange (1O), and two green-orange fusion signals (2GO).
Aberrant Cell (typical results): One orange (1O), and two green-orange fusion (2GO) (adjacent green and orange) signals. In t(12;21) cases the normal ETV6 at 12p13 is often deleted.
- Romana et al (1995) Blood 85:3662-3670
- Sato et al (1997) Blood 90:4886-4893